What are the causes of congenital absence of vagina?

Congenital absence of vagina is a relatively serious gynecological disease. If not treated in time, it will affect everyone's health, so everyone must find a way to treat it correctly. The prerequisite for correct treatment is to understand the cause of congenital absence of vagina. Next, let's take a detailed look at it.

The cause of congenital absence of vagina is mainly during the embryonic development period. When the reproductive system develops, there is a brief stagnation of development due to some reason. It may be due to gene mutation causing chromosomal mutation, or it may be due to the mistaken taking of certain medicines in early pregnancy, such as progesterone and anti-epileptic drugs. The ingredients in the medicines affect the normal development of the reproductive system.

In the past, the most common method used was the patient's own medium-thickness free skin graft. However, after surgery, a hard vaginal mold needs to be used for a long time to expand the artificial vagina to prevent the artificial cavity covered by the grafted skin from contracting, which increases the patient's pain and brings great inconvenience to the workers and life. Moreover, the difference in the characteristics of skin and mucosal tissue is too great, and it does not meet physiological requirements, which is its biggest disadvantage. Vaginoplasty using labia skin flaps destroys the normal vulva shape and is often rejected by patients. Reconstruction using sigmoid colon or ileum segments increases the complexity of the operation. Covering with amniotic membrane or pelvic peritoneum also has its own disadvantages.

Most patients with congenital angular vagina only have completely closed vaginal vestibule mucosa at the normal vaginal opening, with no vaginal traces. Some patients also have shallow depressions in the vaginal vestibule, and some have blind vaginas shorter than 3 cm. It is often accompanied by no deformity, and only slightly thickened strips of tissue can be seen in the normal uterus, located in the middle of the broad ligament. About 1/10 patients may have partial uterine body development and functional endometrium. After puberty, due to menstrual blood retention, periodic abdominal pain occurs, no menstruation, or it is not discovered until after marriage when they seek medical examination due to sexual intercourse difficulties.

Regarding the cause of congenital absence of vagina, we must have an accurate grasp of it. Understanding the cause of congenital absence of vagina is to help us reach a positive understanding and accurate treatment needs. In addition, we also need to make a detailed interpretation of the symptoms of congenital absence of vagina and the diagnosis methods.