Can hyperprolactinemia be cured?

In today's fast-paced life and high work pressure, many women suffer from endocrine disorders due to excessive psychological pressure. For example, hyperprolactinemia is a disease that is common among women. Don't worry too much about hyperprolactinemia. Get treatment in time. Choose drug treatment, surgical treatment or radiotherapy according to the condition. Pay attention to healthy exercise, improve physical fitness, and strengthen physical exercise at ordinary times. If you get treatment in time, there is hope of cure.

Treatment of hyperprolactinemia:

1. Treatment of the cause and primary disease

For example, eliminate adverse mental stimulation, stop taking HPRL-inducing drugs, and actively treat primary diseases such as pituitary tumors, hypothyroidism, Cushing's disease, etc.

2. Anti-prolactin-bromocriptine therapy

Bromocriptine is a semi-synthetic ergot alkaloid derivative and a dopamine receptor agonist. It can promote the synthesis and secretion of PRL-IH and inhibit the synthesis and release of PRL through the receptor mechanism. It also directly acts on pituitary tumors and PRL cells to curb tumor growth and inhibit the secretion of PRL, GH, TSH and ACTH.

Bromocriptine therapy is suitable for all types of HPRL and is also the first choice for pituitary adenomas (micro/macroadenomas), especially for young infertile women who are looking forward to having children. The dose is 2.5-7.5 mg/d, taken orally. Other anti-prolactin drugs include: levodopa (Levo-Dopa), octahydrobenzoquinoline (CV205-502), vitamin B6, etc. For details, please refer to the anti-prolactin section of the endocrine therapy chapter.

3. Ovulation induction therapy

It is suitable for patients with HPRL, anovulatory infertility, and those who cannot successfully ovulate and become pregnant with bromocriptine alone. That is, a comprehensive therapy with bromocriptine as the main drug and other ovulation-inducing drugs: ① bromocriptine-CC-hCG. ② bromocriptine-hMG-hCG; ③ GnRH. Pulse therapy-bromocriptine, etc. The comprehensive therapy can save anti-prolactin, shorten the treatment cycle, and increase the ovulation rate and pregnancy rate.

4. Surgical treatment

It is suitable for patients with giant adenomas that present compression symptoms, as well as patients with drug-resistant tumors, patients who are unresponsive to bromocriptine treatment, and patients with septicomas that secrete multiple pituitary hormones.

The current transsphenoidal microsurgery is safe, convenient, and easy to perform, and its efficacy is similar to that of bromocriptine therapy. The use of bromocriptine before and after surgery can improve the efficacy. The disadvantages of surgery are: if the pituitary tumor has no obvious capsule and unclear boundaries, the surgery is not easy to be thorough or may cause damage, resulting in cerebrospinal fluid nasal fistula and secondary hypopituitarism.

5. Radiation therapy

It is suitable for non-functional tumors of the HP system and those who have not responded to drug and surgical treatment. Irradiation methods include: deep X-ray, 60Co, α particles and proton rays. Isotope 90 yttrium, 198 gold pituitary implantation, etc.