There are four major treatments for hyperprolactinemia

Hyperprolactimia is the most common pituitary disease, with galactorrhea and hypogonadism as prominent manifestations. So, how to treat it? Currently, many experts believe that there are four main treatments, which are introduced in detail below.

1. Antiprolactin drugs: Antiprolactin drugs include bromocriptine, long-acting bromocriptine, tergoline, cabergoline, tergoline, methylergoline, quinagoline (Nogonin) and lisuride.

2. Ovulation induction therapy: It is suitable for patients with hyperprolactinemia, anovulatory infertility, and those who cannot successfully ovulate and become pregnant with bromocriptine alone. It is a comprehensive therapy mainly based on bromocriptine and combined with other ovulation induction drugs:

1. Bromocriptine-CC-hCG.

2. Bromocriptine-hMG-hCG.

3. GnRH, pulse therapy - bromocriptine, etc., combined therapy can save anti-prolactin drugs, shorten the treatment cycle and increase ovulation rate and pregnancy rate.

3. Surgical treatment: It is suitable for patients with giant adenomas and symptoms of intracranial compression, who are ineffective in bromocriptine treatment, giant adenomas, and chromatin cell tumors that secrete multiple pituitary hormones. The current transsphenoidal microsurgery is safe, convenient, and easy to perform, and its efficacy is similar to that of bromocriptine therapy. The combination of bromocriptine before and after surgery can improve the efficacy. The disadvantages of surgery are that pituitary tumors have no obvious capsule and unclear boundaries, making it difficult to perform a thorough operation or causing damage, leading to cerebrospinal fluid nasal fistula and postoperative hypopituitarism. It is worth noting that although preoperative bromocriptine treatment can shrink the tumor, it can cause tumor fibrosis, sclerosis, and adhesion of surrounding tissues, which is not conducive to surgical separation and resection. Therefore, if surgery is confirmed, medication can be temporarily stopped before surgery, and medication or radiotherapy can be supplemented after surgery.

4. Radiotherapy: It is suitable for non-functional tumors of the hypothalamus-pituitary system and those who have not responded to drug and surgical treatment. Currently, advanced stereo focused radiotherapy methods are mostly used, including: deep X-rays, γ, 60Co, α particles and proton rays, radionuclide 90Y, 198Au pituitary implants, etc.