Is hyperprolactinemia dangerous?

What are the hazards of excessive prolactin? The secretion of prolactin is affected by many factors. In addition, drugs such as progesterone, dexamethasone, adrenal cortisol, and acute stress such as strenuous physical activity and trauma can cause increased secretion of prolactin. The hazards of hyperprolactinemia are very great. Let's take a look at the hazards it can bring.

What are the hazards of excessive prolactin? The secretion of prolactin is affected by many factors. In addition, drugs such as progesterone, dexamethasone, adrenal cortisol, and acute stress situations such as strenuous physical activity and trauma can cause increased secretion of prolactin. If the level of prolactin in the blood is too high, it is called hyperprolactinemia. These people often have symptoms of breast tenderness, galactorrhea, scanty menstruation, and even amenorrhea. Therefore, it is sometimes called galactorrhea-amenorrhea syndrome. Among patients with hyperprolactinemia, about 1/4 are caused by pituitary tumors, and some may be caused by hypothalamic and pituitary dysfunction, hypothyroidism, renal insufficiency, malignant tumors in other parts, chest wall damage, and drug effects. Increased prolactin can greatly inhibit the normal secretion of pituitary gonadotropins (such as follicle-stimulating hormone and luteinizing hormone), affecting the normal development of follicles, ovulation function, and pregnancy function. The decrease in the secretion of follicle-stimulating hormone will directly lead to the developmental disorder of the ovarian follicles, which will become weak or incomplete (B-ultrasound observation can show follicles with a diameter of less than 18 mm or smaller), and ultimately, conception will not occur. The insufficient secretion of progesterone (luteinizing hormone) will cause the corpus luteum to have imperfect function, making it difficult to maintain the fertilized follicles to continue to implant and develop (if the basal body temperature is tested, it will show a low temperature phase below 36.8°C), making it difficult to get pregnant, and even if conception occurs, miscarriage is very likely to occur.

The above is an introduction to the dangers of hyperprolactinemia. I hope it will be helpful to you.