What causes endometrial thickening?

Endometrial thickening is common in middle-aged women over 35 years old. It has a certain tendency to become cancerous, so it is classified as a precancerous lesion. This has a great impact on women's physical and mental health. So, what are the causes of endometrial thickening? The following is a detailed introduction to the causes of endometrial thickening.

Causes of endometrial thickening include:

1. Obesity: In obese women, androstenedione secreted by the adrenal glands is converted into estrone by aromatase in adipose tissue. The more adipose tissue there is, the stronger the conversion capacity is, and the higher the estrone level in the plasma is, thus causing a persistent estrogen effect.

2. Endocrine functional tumors: Endocrine functional tumors are rare tumors, accounting for 7.5%. The gonadotropin function of the pituitary gland is abnormal, and ovarian granulosa cell tumors are also tumors that continuously secrete estrogen.

3. Simple endometrial hyperplasia: The lesioned uterus is slightly larger, and the endometrium is significantly thickened, sometimes in a diffuse polyp-like state. The amount of curettage material is large, and may be mixed with red, smooth polyp-like tissue. Microscopically, the lesion is diffuse, involving the functional layer and basal layer of the endometrium. Due to the simultaneous proliferation of the stroma and glands, there is no glandular crowding. The glands vary in size and have smooth contours. The morphology of glandular epithelial cells is similar to that of the normal late proliferation stage, without atypia.

4. Complex endometrial hyperplasia: The etiology of complex hyperplasia is roughly similar to that of simple hyperplasia, but because the lesions are focal, it may also be related to the distribution of hormone receptors in the tissue. A small number of complex hyperplasias can develop into atypical hyperplasias, which affects the prognosis. The diseased endometrium can be thickened or very thin, or it can be polyp-like. Unlike simple hyperplasia, the lesion is a focal hyperplasia of glandular components without involving the stroma. The amount of curettage material can be more or less, and is often mixed with normal, atrophic or other types of hyperplastic endometrium.

Because each person's living environment and physical condition are different, the causes of endometrial thickening are also different, so you need to go to a professional medical institution for specific examination.