Vulvar leukoplakia can become cancerous

Grandma Jia is 61 years old. Since more than 40 years ago, she has had symptoms of vulvar itching from time to time without obvious causes, without pain or other discomfort. She has also been treated intermittently, but has never been cured. Two months ago, she accidentally found a coin-sized lump on the labia majora, which felt very hard, so she went to the hospital for examination. After the doctor saw her, he conducted a systematic examination on her. The gynecological examination showed that her vulva was married type, and linear and flaky white spots could be seen on the vulva. The labia majora on both sides were atrophied and white, the labia minora on the left were white and swollen, and the labia minora on the right were also white and slightly atrophied. A 3cm×3cm×4cm hard mass was seen on the left labia majora, with ulcers on the surface, and pus could be squeezed out. The patient's vagina was extremely narrow and the inner wall was smooth. A biopsy was taken for pathological examination, which showed that the vulvar tissue showed papilloma-like changes under the microscope, some cells were slightly atypical, and nuclear division was visible. The diagnosis was vulvar leukoplakia.

Vulvar leukoplakia is a chronic vulvar malnutrition disease. According to the differences in its tissue pathology, it can be divided into hyperplastic, lichenified and mixed types. Vulvar leukoplakia has a canceration rate of 5% to 10%. It often occurs in patients with atypical epithelial hyperplasia, manifesting as carcinoma in situ or invasive cancer, and rarely develops into squamous cell carcinoma. Therefore, for those older patients with vulvar leukoplakia who have not been cured for a long time, the changes in the condition should be closely observed, and pathological examinations should be performed when necessary, so as to detect and treat them in time to prevent accidents.