Analysis of the most common causes of uterine fibroids

It is understood that many female friends are unable to conceive because they have not received timely treatment for certain gynecological diseases, including uterine fibroids, which have a great adverse impact on women's health and need to be prevented as soon as possible. What are the common causes of uterine fibroids ? The following is a list of the common causes of uterine fibroids.

In general, the common causes of uterine fibroids are:

In recent years, along with the research on the causes of uterine fibroids and endocrine, experiments have confirmed that fibroid tissue has estrogen receptors (ER) and progesterone receptors (PR), and their density exceeds that of surrounding normal muscle tissue. ER and PR change with the menstrual cycle. It has been reported that uterine fibroids increase in size after the use of exogenous hormones and clomiphene. Inhibiting or reducing sex hormone levels can prevent fibroid growth, shrink fibroids and improve clinical symptoms, suggesting that fibroids are sex hormone-dependent tumors. Antagonistic hormone drugs can be used to treat fibroids, but clinical measurements of peripheral blood sex hormones in fibroid patients and women without fibroids show no significant difference. This is a common cause of uterine fibroids.

The cause of uterine fibroids is not so much related to the hormonal environment of the fibroid patient as it is to the abnormal local endocrine environment of the fibroid itself. For example, the estrogen concentration in fibroids is higher than that in uterine muscles; the endometrium near fibroids is highly proliferative, etc. The same is true for receptors. The content of E (estradiol receptor) and PR in fibroids is higher than that in uterine muscles.

It has long been known that uterine fibroid cells originate from smooth muscle cells of the uterine muscle and blood vessel walls, such as immature myoblasts, but the latter has not yet been clearly defined in histology. Histological studies have found that small uterine fibroids that have not grown for a long time not only have mature smooth muscle cells rich in myofibrils, but also immature smooth muscle cells found in the fetal uterus. This shows that the occurrence of human uterine fibroids may come from the differentiation process of undifferentiated mesenchymal cells into smooth muscle cells. The cause of uterine fibroids may be due to the fact that the origin cells are often latent in the myometrium of the uterus, judging from multiple uterine fibroids. This is a relatively common cause of uterine fibroids.

The above analysis is the common cause of uterine fibroids, I hope it will be helpful to everyone. If you have any questions about the cause of uterine fibroids, you can consult our online experts, they will answer you in detail.