Does adenomyosis affect pregnancy?

Can I get pregnant with adenomyosis? Adenomyosis, also known as uterine fibroids, is a pathological change that occurs in the endometrium of women. Because it occurs in the uterus, it will inevitably have a certain impact on pregnancy. It is difficult to get pregnant with adenomyosis, but it does not mean that adenomyosis will definitely lead to female infertility. However, if you get pregnant, as the fetus grows and develops, it will definitely have a certain impact on the fetus and the woman herself.

Does adenomyosis affect pregnancy?

Adenomyosis is a benign disease caused by the invasion of the endometrium into the myometrium. Histopathologically, the myometrium is thickened, the endometrial glands are arranged in islands, the myometrial stroma is proliferated, and there is smooth muscle fibrosis. The main symptoms are dysmenorrhea, increased menstrual flow, and uterine enlargement. Diffuse hyperplasia of the myometrium was once called endometriosis. Does adenomyosis affect pregnancy?

Experts say that adenomyosis is closely related to female infertility, and many patients with adenomyosis often cannot become pregnant.

[No clear conclusion]

It has not been clearly determined whether adenomyosis causes infertility. Because adenomyosis is often accompanied by endometriosis, it is difficult to completely separate the cause of decreased fertility. The cause of infertility caused by adenomyosis may be endometriosis, adhesion of lesions, and in severe cases, the obstruction of egg collection and transportation. At the same time, the autoimmune response of endometriosis affects sperm activity, etc.

[Mechanism still unclear]

Does adenomyosis affect pregnancy? The mechanism of infertility and early miscarriage in patients with adenomyosis is still unclear. It may be related to nitrogen oxides and potential vasodilation. Studies in recent years have shown that there is nitric oxide synthesis and vascular epithelial cell formation in the endometrial glandular epithelium. The synthesis of nitrogen oxides in the endometrium varies with the menstrual cycle, especially in the second trimester. Endothelial cells produce a large amount of nitrogen oxides, which hinder fertilization and implantation. Even after implantation, the embryo will be attacked by activated macrophages and T cells, leading to miscarriage.

The biggest concern about adenomyosis is whether it will affect fertility and cause infertility. It is generally believed that severe adenomyosis, especially in patients with endometriosis, can easily lead to infertility. Such patients have enlarged uterus and are prone to pelvic adhesions, which are not conducive to ovulation and embryo implantation, and the natural pregnancy rate is not high.