What is the cause of uterine fibroids?

What is the cause of uterine fibroids? The incidence of uterine fibroids is very high in our daily life. It is the most common benign tumor in the female reproductive organs. There are many factors that cause the disease. Therefore, we can only prevent the occurrence of the disease if we understand the cause of the disease. So, what is the cause of uterine fibroids?

1. General factors: Uterine fibroids mostly occur in women of childbearing age, most commonly in women aged 30-50, and rarely in adolescent women. Uterine fibroids shrink or disappear after menopause. Obesity can cause metabolic disorders, leading to a lack of cyclical regulation of progesterone, causing abnormal menstrual cycles, affecting ovulation, and increasing the risk of uterine fibroids.

Women with a history of pregnancy and childbirth are more likely to develop uterine fibroids than women without a history of pregnancy and childbirth, and the age of onset is earlier, mainly because menstruation can increase the progesterone in women's bodies. Smoking and drinking can easily induce uterine fibroids. Studies have shown that women who smoke a pack of cigarettes a day are 6 times more likely to develop uterine fibroids than non-smoking women.

2. Hormone level: Biochemical tests have confirmed that the conversion of estradiol to estrone in fibroids is significantly lower than that in normal muscle tissue, and the concentration of estrogen receptors in fibroids is significantly higher than that in surrounding muscle tissue. Therefore, it is believed that the high sensitivity of local fibroid tissue to estrogen is one of the important factors in the occurrence of fibroids. Progesterone has the effect of promoting fibroid mitosis and stimulating fibroid growth. If the level of progesterone in women is high, it is easy to induce uterine fibroids.

3. Genetic factors: Cytogenetics shows that 25%-50% of uterine fibroids have cytogenetics abnormalities, such as chromosome segment position exchange, chromosome long arm rearrangement or partial deletion, etc. Uterine fibroids are formed by the proliferation of monoclonal smooth muscle cells, and multiple uterine fibroids are formed by different clones of cells.

In addition, ovarian function and hormone metabolism are controlled and regulated by higher nerve centers, so the activity of nerve centers may also play an important role in the onset of fibroids. Uterine fibroids are more common in women of childbearing age, widowed women, and women with unbalanced sexual lives. Chronic pelvic congestion caused by long-term sexual dysfunction may also be one of the causes of uterine fibroids. In short, the occurrence and development of uterine fibroids may be the result of the combined action of multiple factors.