Is immunotherapy necessary for abortion?

When visiting the clinic, you can see that many doctors recommend immunotherapy for patients with multiple miscarriages, but most patients do not know why they need immunotherapy. So many patients will ask such a question: Is immunotherapy necessary for miscarriage? Let me answer it for you below.

Most miscarriages have a certain development process. Although some stages are not obvious in clinical manifestations and do not necessarily develop in sequence, they generally include the following processes, namely the clinical classification: threatened miscarriage, inevitable miscarriage, incomplete miscarriage and complete miscarriage. Postponed miscarriage is another special case of miscarriage development. Habitual miscarriage is named after its characteristic of repeated miscarriage, but both still include the above clinical classifications in the process of miscarriage.

To know whether immunotherapy is necessary, the patient must first confirm the type of miscarriage. Except for habitual miscarriage, other types of miscarriage can be basically cured by targeted treatment after the cause is found. However, for patients with habitual miscarriage, immunotherapy is imperative.

The causes of habitual abortion are complex, mainly including genetic defects, anatomical abnormalities, endocrine abnormalities, immune factors, infections, systemic diseases and environmental factors. Among them, the incidence of unexplained habitual abortion is about 50%. Therefore, it is of great significance to explore its causes and take appropriate and effective treatment methods according to the causes.

A large number of clinical practices at home and abroad have shown that active immunotherapy using the husband's or a third party's lymphocytes is a relatively safe and effective method. Active immunotherapy can induce and stimulate the mother to produce alloimmune responses, produce antibodies that have immune protection effects on the embryo of the next pregnancy, and prevent the fetus from being attacked by the mother's immune system, allowing the pregnancy to continue. Its success rate can reach 85% to 90%.

Before immunotherapy, make sure that the man does not suffer from blood-borne infectious diseases (such as hepatitis, HIV infection, etc.), draw 50 ml of peripheral anticoagulant blood from the husband or a third party, separate 2 ml of lymphocytes with lymphocyte separation fluid, and give it subcutaneously to the woman. Each injection should be done 3 to 4 weeks apart (avoid the menstrual period), and each course of treatment should be 3 times.

The first three times of pregnancy constitute one course of treatment. After the course of treatment, the antibody is rechecked. After the antibody turns positive, the patient is encouraged to get pregnant as soon as possible within six months. After the pregnancy is confirmed, 2 to 3 more active immunotherapy treatments are carried out to consolidate the therapeutic effect.

Lymphocyte immunotherapy has been widely used around the world and is currently a relatively safe and effective method for treating unexplained habitual abortion.