Is there a genetic factor for congenital absence of vagina?

Is there a genetic factor for congenital absence of vagina? Congenital absence of vagina is often associated with uterine hypoplasia, which may be caused by chromosomal abnormalities, androgen insensitivity syndrome, androgen use, anticancer drugs, thalidomide and other drugs in the early pregnancy of the mother, or infection with certain viruses. It causes periodic abdominal pain and sexual dysfunction, so we should pay attention to the cause of congenital absence of vagina and do a good job of prevention and treatment as soon as possible.

1. Reasons

1. Infection with certain viruses or toxoplasma in early pregnancy may cause congenital absence of vagina in baby girls.

2. The mother used male hormone anti-cancer drugs such as thalidomide in early pregnancy.

3. Androgen insensitivity syndrome or chromosomal abnormalities.

In short, the causes of congenital absence of vagina must be clearly understood, and preventive measures should be actively taken in the early stages of pregnancy to avoid the occurrence of congenital absence of vagina.

Pathogenesis

Congenital absence of vagina occurs when the sexual organs are differentiated and formed at about 7-10 weeks of the embryonic period. After the two paramesonephric ducts merge, their tail ends are blocked or stagnant and fail to develop downward. Patients with congenital absence of vagina have normal external genitalia, with or without hymen, and a shallow depression or short lower vagina at the vaginal opening. The vast majority of patients with congenital corner vagina only have completely closed vaginal vestibule mucosa at the normal vaginal opening, with no vaginal traces. Some have blind vaginas shorter than 3 cm. It is often accompanied by no deformity. In the normal uterus, only slightly thickened strip-like tissue is seen, located in the middle of the broad ligament.

3. Treatment:

After detailed examination, if the patient has a nearly normal uterus and normal ovarian function, the surgery should be performed after the menarche to facilitate menstrual blood drainage and sexual intercourse, and there is hope for intrauterine pregnancy after treatment. If the patient has no uterus or primordial uterus and is not likely to have children, it is best to perform artificial vaginoplasty before or after marriage to mainly solve the problem of sexual life.

For those who are infertile and have a partial blind bag-like vagina, local pressure method can be tried according to the patient's wishes. A round and blunt mold like the bottom of a test tube can be used for long-term self-pressure. Sexual life can also be gradually deepened. If you are not satisfied, it also creates better conditions for surgery.

There are many surgical procedures, such as labia minora flap vaginoplasty, inner thigh skin flap vaginoplasty, sigmoid colon vaginoplasty, peritoneal vaginoplasty, etc. For specific methods, please refer to gynecological surgery. If pregnancy occurs after surgery, it should be closely monitored, and cesarean section should be selected if the due date is close.

The vast majority of patients with congenital absence of vagina only have completely closed vaginal vestibule mucosa at the normal vaginal opening, with no trace of vagina. Some patients also have shallow depressions in the vaginal vestibule, and some have blind vaginas shorter than 3 cm. It is often accompanied by no deformity, and only slightly thickened strips of tissue are seen in the normal uterine position, located in the middle of the broad ligament. About 1/10 patients may have partial uterine body development and functional endometrium. After puberty, due to menstrual blood retention, periodic abdominal pain occurs, and there is no menstruation or it is not until after marriage that it is discovered through medical examination due to sexual intercourse difficulties. If you have similar related symptoms, please check and treat them in time. I sincerely wish you good health and a happy life.