Congenital absence of vagina

What is the authoritative knowledge about congenital absence of vagina? This is one of the vaginal abnormalities. Congenital absence of vagina is a common malformation of female genitalia. This disease is caused by the obstruction of the embryo during development by internal or external factors, or it may be caused by abnormal development of the paramesonephric duct due to gene mutation (may have a family history).

The original vagina in the middle of the perineum of patients with congenital vaginal absence is flat or has only a shallow pit. People without vagina often also have no uterus, and the fallopian tubes are relatively small or even absent, but the ovaries are normal. When such women reach puberty, their ovaries gradually mature and secrete female hormones as usual, promoting the formation of secondary sexual characteristics. The development of body shape, voice tone, pubic hair, armpit hair, etc. is completely normal, and they are still charming and graceful ladies.

The most common patients with Rokitansky-Kustner-Hauser syndrome are characterized by normal female chromosome karyotype, normal growth and development of female secondary sexual characteristics, normal vulva, vaginal absence, uterine development (only remnants of two horns), small fallopian tubes, and normal ovarian development and function. Testicular feminization (androgen insensitivity syndrome) is relatively rare. Very few are true hermaphroditism or gonadal dysgenesis.