Drug-induced hyperprolactinemia and its treatment

Many friends at work rarely have time to pay attention to women's health. How to treat hyperprolactinemia? Hyperprolactinemia is common in gynecological endocrine diseases. The body is affected by internal and external environmental factors (physiological or pathological), and the level of prolactin in the blood increases. When the increase reaches a certain standard, it is called hyperprolactinemia. So, how to treat hyperprolactinemia?

How to treat hyperprolactinemia:

1. Surgical treatment

It is suitable for patients with giant adenomas that present compression symptoms, as well as patients with drug-resistant tumors, patients who are unresponsive to bromocriptine treatment, and patients with septicomas that secrete multiple pituitary hormones.

2. Treatment of the cause and primary disease

How to treat hyperprolactinemia? Such as eliminating adverse mental stimulation, stopping the use of HPRL-inducing drugs, and actively treating primary diseases such as pituitary tumors, hypothyroidism, Cushing's disease, etc.

3. Radiation therapy

It is suitable for non-functional tumors of the HP system and those who are ineffective with drug and surgical treatment. How to treat hyperprolactinemia? Irradiation methods include: deep x-ray, 60co, alpha particles and proton rays. Isotope 90yttrium, 198gold pituitary implantation, etc.

IV. Ovulation induction treatment

It is suitable for patients with HPRL, anovulatory infertility, and those who cannot successfully ovulate and become pregnant after simple bromocriptine treatment. That is, a comprehensive therapy with bromocriptine as the main drug and other ovulation-promoting drugs: ① bromocriptine-cc-hcg; ② bromocriptine-hmg-hcg; ③ gNRH. Pulse therapy-bromocriptine, etc. Comprehensive therapy can save anti-prolactin, shorten the treatment cycle and increase the ovulation rate and pregnancy rate.

5. Anti-prolactin-bromocriptine therapy

Bromocriptine is a semi-synthetic ergot alkaloid derivative and a dopamine receptor agonist. It can promote the synthesis and secretion of PRL-IH and inhibit the synthesis and release of PRL through the receptor mechanism. It also directly acts on pituitary tumors and PRL cells to curb tumor growth and inhibit the secretion of PRL, GH, TSH and ACTH.

How to treat hyperprolactinemia? Bromocriptine therapy is suitable for all types of HPRL and is also the first choice for pituitary adenomas (micro/macroadenomas), especially for young infertile women who are looking forward to having children. The dose is 2.5-7.5 mg/d, orally. Other anti-prolactin drugs include: levodopa, octahydrobenzoquinoline (cv205-502), vitamin b6, etc. For details, please refer to the anti-prolactin section of the endocrine therapy chapter.

The above is the main content about how to correctly treat hyperprolactinemia. I believe that readers and friends have learned a lot here like me. I hope that you can develop good health behavior habits in your future life to prevent the occurrence of these diseases. Finally, I wish you good health and smooth work!