Clinical manifestations of hyperprolactinemia

Hyperprolactinemia is a very common disease, which seriously affects the physical and mental health of patients and makes them very distressed. So, what are the clinical manifestations of hyperprolactinemia? Next, we will introduce the clinical manifestations of hyperprolactinemia.

The most prominent manifestation of hyperprolactinemia is hypogonadism, which is caused by elevated PRL levels and is called hyperprolactinemic hypogonadism. Female patients may experience decreased libido and loss of sexual desire, which will be relieved after treatment as PRL levels decrease. In women of childbearing age, hyperprolactinemic hypogonadism is mainly manifested by decreased menstruation or even amenorrhea, but it can also be manifested as menorrhagia or normal menstruation with infertility.

Galactorrhea is another common symptom, seen in 30% to 80% of female patients. Most patients have well-developed breasts, which is in sharp contrast to the breast shrinkage of those who have natural menopause. Spontaneous galactorrhea is rare, and milk can only be seen flowing out by squeezing the nipples. Those with high blood PRL levels do not experience galactorrhea, which may be due to the fact that high PRL strongly inhibits the function of the gonads and significantly reduces the estrogen level. Patients with this disease have true galactorrhea, with liquid flowing out of both nipples. It is a milky or turbid white liquid, rich in casein, whey protein and lactose, and should be distinguished from pseudogalactorrhea.