Progesterone hemostasis can treat adolescent functional uterine bleeding

Dysfunctional uterine bleeding, also known as functional uterine bleeding, is uterine bleeding caused by ovarian dysfunction and requires active treatment. Progestin hemostasis can treat functional uterine bleeding in adolescence.

Applicable population for progestin hemostatic therapy

Progestin hemostasis is suitable for patients who already have a certain level of estrogen in their bodies. At this time, the effect of progestin can cause the endometrium to undergo secretory changes and fall off completely. The hemostatic effect occurs after withdrawal bleeding.

Progestin hemostatic therapy

For patients with short bleeding time and little blood loss, 10-20 mg of progesterone can be injected intramuscularly every day for 3-5 consecutive days. You can also take synthetic norethindrone 5-10 mg, megestrol acetate 8-12 mg or medroxyprogesterone 10-16 mg for 5 consecutive days. The lining of the vagina will fall off within 3-5 days after stopping the drug, resulting in a small amount of withdrawal bleeding, which can be clear in 5-7 days. For patients with long bleeding time and heavy bleeding, the dosage should be increased and the medication time should be extended. Starting from the time when the bleeding stops or basically stops, the medication should be continued for 20 days. The following drugs can be taken orally within 4-6 hours: norethindrone 5-7.5 mg, megestrol acetate 8 mg, or medroxyprogesterone 8-10 mg. After 4-6 medications, bleeding should be significantly reduced and stop within 48-72 hours. After the bleeding stops, the dosage should be gradually reduced to about 2.5 mg of norethindrone, 4 mg of megestrol acetate or 4-6 mg of medroxyprogesterone per day, and maintained for about 15-20 days after the bleeding stops. When taking the above drugs, 0.25-0.5 mg of diethylstilbestrol should be taken at the same time, once a night. If a large dose of progesterone cannot stop bleeding within 48-72 hours, it may be caused by low estrogen levels. Try injecting 2-4 mg of estradiol benzoate twice a day. After the bleeding stops, gradually reduce the dosage to about 0.5 mg of diethylstilbestrol per day, and finally stop taking it at the same time as the progesterone.