Biopsy diagnosis of mixed dystrophic vulvar leukoplakia

Vulvar leukoplakia can be classified into hyperplastic dystrophy, lichen sclerosus dystrophy, mixed dystrophy, etc. according to the patient's clinical symptoms. Among them, hyperplastic dystrophy generally occurs in women aged 30 to 60 years old, and the main symptom is unbearable vulvar itching; lichen sclerosus dystrophy is more common in women around 40 years old, and the main symptom is itching in the lesion area; the main symptom of mixed dystrophy is focal skin thickening or bulging in the vicinity of the white area of ​​the vulva or within its range. If vulvar leukoplakia is suspected, a biopsy can be performed to diagnose whether it is mixed dystrophy vulvar leukoplakia

Biopsy diagnosis of mixed dystrophic vulvar leukoplakia

If the patient has focal skin thickening or protrusions adjacent to or within the white area of ​​the vulva, chronic inflammation caused by diabetes or fungi should be ruled out, and vulvar leukoplakia should be suspected. A biopsy should be performed to further confirm the type of vulvar leukoplakia.

The biopsy site should be where there are cracks, ulcers, bulges, nodules or roughness in the whitish area of ​​the patient's vulva. In order to improve the accuracy of diagnosis, the lesion area can be first painted with 1% toluidine blue, and then scrubbed with acetic acid to remove the color after it dries. If the tissue does not discolor after the examination, it means that the skin biopsy is likely to find atypical hyperplasia or cancer, and it can be diagnosed as mixed dystrophic vulvar leukoplakia.