High risk factors for uterine fibroids

The cause of uterine fibroids is the result of the interaction of multiple factors. Do you know the high-risk factors for the onset of uterine fibroids? The onset of uterine fibroids is often closely related to the patient's own physical fitness and lifestyle. Let's take a look at the following 11 causes of uterine fibroids with experts.

There is still no complete and correct conclusion on whether these factors can promote the occurrence of uterine fibroids induced by estrogen and progesterone. However, epidemiological surveys in recent years have found that the following factors may be high-risk factors for the etiology of uterine fibroids.

1. Obesity

Recent studies have found that obesity is positively correlated with the incidence of uterine fibroids. And for every 10kg increase in weight a woman gains, her risk of uterine fibroids increases by 21%, or for every 1 unit increase in body mass index, her risk of uterine fibroids increases by 6%.

2. Age

Late childbearing age is often considered a high-risk age for the development of uterine fibroids.

This age is usually around 40 years old, close to perimenopause. During this period, there may be ovarian ovulation dysfunction. It may also be the result of the cumulative effects of estrogen and progesterone on women for 20 to 30 years during this period.

(III) Oral contraceptives

Current studies have found that whether oral contraceptives can increase the incidence of uterine fibroids depends mainly on the estrogen and progesterone components of the oral contraceptives.

If the oral contraceptive contains high-efficiency, high-dose progestin as the main ingredient, it can reduce the incidence of uterine fibroids; otherwise, it can increase the incidence of uterine fibroids.

If oral contraceptives are used at an early age (<13-16 years old), the incidence of uterine fibroids can be significantly increased.

4. Diet

Although the correlation between diet and the incidence of uterine fibroids often does not attract people's attention, studies have reported that women whose staple food is animal food have a significantly higher incidence of uterine fibroids than women whose staple food is green vegetables.

In addition, eating more vitamins, especially vitamin C, can also reduce the incidence of uterine fibroids.

5. Racial differences

Studies have shown that the incidence of uterine fibroids in African Americans is 3.4 times that of white Americans, while the incidence of uterine fibroids in Orientals is lower than that in Westerners.

Further research found that African Americans have high levels of estrone, estradiol and free estradiol in their bodies, which may promote the occurrence of uterine fibroids.

(VI) Mental factors:

Excessive work stress, excessive pressure, family discord, emotional trauma, bad mood, etc. may cause ovarian dysfunction and lead to uterine fibroids.

(VII) Smoking

The harm of smoking to human health is well known. However, studies have found that smoking can reduce the incidence of uterine fibroids.

It is generally believed that the incidence of uterine fibroids in women who are still smoking can be reduced by 50% compared with non-smoking women, and the amount of smoking is negatively correlated with the incidence of uterine fibroids.

8. Hormone replacement therapy (HRT)

Studies have found that women who use hormone replacement therapy after menopause, whether using estrogen alone or a combination of estrogen and progesterone, can promote the growth of uterine fibroids.

It was also found that women who use hormone replacement therapy after menopause can significantly increase the incidence of uterine fibroids.

(IX) Exogenous estrogen substances

They are mainly toxic substances in the environment, and their mechanism of action is relatively complex. There are substances that antagonize the effects of estrogen, and there are also substances that promote the effects of estrogen.

Recent studies have found that the pesticide used in agriculture - dichlorodiphenyltrichloroethane (DDT) and its analogues have estrogenic effects and can promote the occurrence of uterine fibroids.

10. Age of menarche and number of births

Studies have found that the earlier the age of menarche, the higher the incidence of uterine fibroids.

The incidence of uterine fibroids in women who had their menarche at <12 years of age was significantly higher than that in women who had their menarche at >16 years of age.

Recent studies have found that the incidence of uterine fibroids in fertile women is significantly lower than that in infertile women, and the incidence of uterine fibroids gradually decreases with the increase in the number of pregnancies. The reason may be that pregnancy can reduce the duration of estrogen action.

(11) Genetics

Uterine fibroids do not have an obvious genetic tendency. However, fibroids often appear in women in the immediate family. If one of the sisters or mother and daughter in the family has fibroids, the others are likely to have fibroids as well.

The above are the main factors that lead to the etiology of uterine fibroids. I hope it will be helpful to you. In addition, experts recommend that female friends go to the hospital's gynecology department for regular physical examinations to detect latent diseases in time, early detection and early treatment, and improve their diet and exercise their bodies.

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