What are the causes of uterine fibroids? Common hazards of uterine fibroids

Submucosal fibroids account for about 10% of uterine fibroids, that is, intramural fibroids grow in the uterine cavity and block the cervix or detach from the vagina. So, what is the cause of uterine fibroids? What are the hazards? As early as the early 1990s, Rein pointed out that somatic mutations are the starting events of fibroid formation. Somatic mutations include various chromosomal aberrations from point mutations to chromosome loss and gain. The first is somatic mutations of monoclonal origin, which provide selective growth advantages for mutant muscle cells, and the second is the rearrangement of various chromosomes associated with fibroids. Cytogenetics consistently confirms that uterine fibroids have abnormal chromosome structure. It is generally believed that 53.9% to 65.6% of uterine fibroid tissue culture are normal karyotypes, and 34.4% to 46.1% are non-random chromosomal abnormal karyotypes.

It is currently believed that the transformation process from myometrial cells to fibroids may involve a complex interaction between somatic mutations of normal myometrium, sex hormones, and local growth factors. Sex hormones, including estrogen, progesterone, and many peptide growth factors, are considered to be regulators of fibroid growth and play an important role in the etiology of fibroids.

What are the hazards of uterine fibroids? The hazards of uterine fibroids include excessive blood loss. Women with uterine fibroids may experience prolonged menstruation and increased bleeding, especially those who delay the disease without effective treatment. They may bleed heavily in a short period of time, leading to severe anemia, which is very harmful to body functions.

The harm of uterine fibroids also includes miscarriage. In some patients, uterine fibroids cause the uterus to enlarge and bend, which can lead to miscarriage. If it is a submucosal fibroid, it will grow into the uterine cavity, causing female spasms and contractions, and miscarriage symptoms. Uterine fibroids may also affect the growth of implanted eggs and lead to miscarriage.