Can taking mifepristone in three months of pregnancy cause abortion? A small number of women have incomplete abortions

Everyone knows that mifepristone is an anti-early pregnancy drug. So will taking this drug after pregnancy cause miscarriage? Let's take a closer look at this drug.

Mifepristone, in addition to being used to prevent early pregnancy, induce menstruation and stop pregnancy, and induce labor for intrauterine fetal death, is also used in gynecological surgical procedures, such as the placement and removal of intrauterine contraceptive devices, taking endometrial specimens, laser separation of cervical canal developmental abnormalities, and cervical dilation and curettage.

Pharmacology: It is a strong anti-progestin, which can bind to progesterone receptors and glucocorticoid receptors. Its affinity for endometrial progesterone receptors is 5 times stronger than that of progesterone. It has an abortion-inducing effect on pregnant animals at all stages of pregnancy and can be used as a non-surgical anti-early pregnancy drug. It has no significant effect on cortisol levels at effective doses. Since the drug cannot induce sufficient uterine activity, the incomplete abortion rate is high when used alone to prevent early pregnancy, but it can increase the sensitivity of the uterus to prostaglandins. Therefore, adding a small dose of prostaglandins can not only reduce the adverse reactions of prostaglandins, but also significantly increase the complete abortion rate (to more than 95%). This product also has the effect of softening and dilating the cervix. Oral tmax is 1-3 hours, bioavailability is 70%, plasma protein binding rate is 98%, and elimination t1/2 is about 18 hours. Generally, vaginal bleeding begins 30 hours after oral administration and lasts for 1-16 days.

In addition to being used to prevent early pregnancy, induce menstruation and stop pregnancy, and induce labor for intrauterine fetal death, it is also used in gynecological surgical operations, such as placement and removal of intrauterine contraceptive devices, taking endometrial specimens, laser separation of cervical canal developmental abnormalities, and cervical dilation and curettage.

Dosage and Usage: Due to different dosage forms and specifications, please read the drug instructions carefully or follow the doctor's advice on usage and dosage.

Adverse reactions include nausea, vomiting, dizziness, abdominal pain, etc. Pain caused by uterine cramps can be treated with analgesics.

Contraindications include patients with heart, liver, kidney diseases and adrenal cortical insufficiency, long-term corticosteroid treatment, ectopic pregnancy, bleeding disorders, patients who are not compliant with treatment and medication, patients who do not understand the effects of treatment, porphyria, intrauterine device (IUD), and those with allergies.

Precautions (1) Patients with severe reactions, frequent nausea and vomiting during early pregnancy should not use this product to avoid aggravating the reaction. (2) Patients diagnosed with early pregnancy should not have their menstrual period last for more than 49 days. The shorter the pregnancy period, the better the effect. (3) When this product and prostaglandins are used sequentially to treat early pregnancy, a small number of women may experience incomplete abortion, which can cause heavy bleeding. Therefore, this product must be used under the supervision of a doctor and treated in a timely manner. (4) After taking the medicine, a small amount of vaginal bleeding will generally occur. A small number of women have experienced abortion before taking prostaglandins. About 80% of pregnant women expel the chorionic foetal sac within 6 hours after taking prostaglandins, and about 10% of pregnant women expel the foetal sac within one week after taking the medicine. (5) Patients should see a doctor 8 to 15 days after taking the medicine to determine the abortion effect. If necessary, ultrasound examination or blood chorionic gonadotropin (HCG) measurement can be performed. If abortion failure or incomplete abortion is confirmed, vacuum aspiration should be performed to terminate the pregnancy or clean the uterine cavity. (6) All doctors or patients who perform abortions should consider carefully before using this product, because this product may have some special risks, such as sepsis. (7) Because this product must be used sequentially with prostaglandins, it is not suitable for people with contraindications to prostaglandins, such as glaucoma, asthma, and allergic constitutions, to use mifepristone. Pregnant women over 35 years old and women who smoke should avoid using it.