How to check for recurrent miscarriage

Recurrent miscarriage is called "slippery abortion" in traditional Chinese medicine. It refers to more than 3 spontaneous miscarriages, and each miscarriage occurs in the same month of pregnancy. The main cause of recurrent miscarriage is luteal insufficiency and some autoimmune reasons. So how to check for recurrent miscarriage?

Diagnostic tests

1. General diagnosis includes medical history inquiry (internal and external medicine, obstetric history, metabolic history, infection, whether there is foreign body in the uterus, drug poisoning, radiation therapy, etc.), physical examination and pelvic examination should pay attention to the size and position of the uterus, the condition of the appendages, basal body temperature measurement, endometrial examination, hysterosalpingography, and hysteroscopy and laparoscopy when necessary. Laboratory examination includes blood routine, erythrocyte sedimentation rate, blood type and semen routine.

2. Special Inspection

1. For those suspected of having a genetic disease, both the husband and wife should undergo a chromosome karyotype examination, or further conduct a family genetics survey and pedigree drawing of the couple.

2. Hormone determination, including quantitative detection of estrogen, progesterone, human chorionic gonadotropin, etc.

3. Culture urine and cervical mucus to find out whether there is microbial infection.

4. Research on the pathological anatomy and cytogenetics of pregnancy products after abortion.

5. Patients suspected of having autoimmune diseases should be tested for APA. After the above comprehensive examinations, if the common causes are excluded one by one and the cause is still unknown, it should be suspected to be immune recurrent miscarriage and immunological examinations should be performed.

3. Immunological examination

1. First, use the mixed lymphocyte culture reaction (MLR) and lymphocyte toxicity antibody assay to distinguish primary from secondary abortion.

2. Determination of antisperm antibodies.

3. Blood type and anti-blood type antibody determination.