Research progress on the causes of missed abortion

Missed abortion is a special type of spontaneous abortion. The incidence of missed abortion has been increasing over the years. Medical experts have also done a lot of research on this special type of abortion. From the current progress, a lot of relevant research has been done on the diagnosis and treatment of missed abortion, but there are fewer studies on the causes of missed abortion. Therefore, this article aims to describe the progress of research on the causes of missed abortion.

The phenomenon that the embryo remains in the female uterine cavity after death and has not been naturally expelled from the body for two months is called missed abortion. The analysis of the causes of missed abortion is as follows.

Ureaplasma urealyticum infection is the main cause of missed abortion. Ureaplasma urealyticum is the smallest microorganism that has no cell wall and can survive independently, between bacteria and viruses. It mainly parasitizes the mucosa of the urogenital tract and only becomes infected when certain susceptible conditions are met. When it reaches a certain value or is mixed with other microorganisms, it can cause endometritis and acute salpingitis. Lai Tieying and other studies have shown that genital tract UU infection has an important relationship with missed abortion and is an important cause of missed abortion. This study shows that the positive rate of UU infection in missed abortion is 39.3%

Chlamydia trachomatis is a special pathogen with a cell wall similar to that of Gram-positive bacteria. It is a specialized intracellular lysosome with DNA, RNA and complete cell membrane. It inhibits intracellular lysosomes, thus avoiding the destruction of the main body, so that it can stably parasitize in host cells and develop slowly. When the body's resistance decreases, DNA and RNA can be adsorbed in host cells and reproduce. CT easily invades columnar epithelial cells, so the cervix is ​​an important place for CT to invade. If cervical infection with CT is not treated in time, it can cause persistent infection, causing pelvic inflammatory disease, endometritis, etc. About 30-40% of cervical canal infection with CT extends to the endometrium. At the same time, the increased hormones during pregnancy can increase the toxicity of CT and damage the developing embryo. This data study shows that the positive rate of CT infection in missed abortion is 14.3%.

Progesterone deficiency can lead to endometrial hypoplasia, hindering the implantation of fertilized eggs and early embryonic development. Progesterone levels gradually increase throughout pregnancy, rising slowly in the early stages, accelerating in the middle stages, and reaching a peak at full-term pregnancy. The change in progesterone levels is a reliable indicator of whether corpus luteum function and placental development are normal. Progesterone maintains a certain level before 12 weeks of pregnancy, with no significant difference at each gestational week. The progesterone level is low during missed abortion, which basically reflects the functional status of the corpus luteum during blood sampling, and has obvious value in diagnosing abnormal pregnancy or guiding treatment. Studies have shown that the incidence of progesterone deficiency is 25.6%.

In conclusion, missed abortion has been increasing in recent years. It is recommended that governments at all levels and the tertiary health care network strengthen the supervision of high-risk production environments, implement the labor protection system, and actively carry out reproductive health education and services in various ways and through various channels for couples of childbearing age at different cultural levels. Efforts should be made to do a good job in premarital and pre-pregnancy examinations and consultations, strengthen perinatal health care, improve the success rate of pregnancy, and reduce the incidence of missed abortion. Patients diagnosed with unexplained missed abortion in the clinic should be tested for mycoplasma and chlamydia. Early diagnosis and treatment of UU and CT can also reduce the incidence of missed abortion.