What is the cause of congenital absence of vagina in women?

What is congenital absence of vagina? Most patients with congenital absence of vagina suffer from congenital absence of vagina syndrome (MRKH), in which there is no vagina and the uterus is absent at the same time, showing primary amenorrhea or dyspareunia. The incidence of congenital absence of vagina is about 1/5000, which is the result of incomplete development of bilateral mesonephric ducts. Almost all of them are accompanied by absence of uterus or primordial uterus, and occasionally with functional uterus. The bilateral fallopian tubes and ovaries are generally developed normally.

There are three main reasons for congenital absence of vagina:

1. The mother used male hormones, anticancer drugs, thalidomide, etc. in early pregnancy.

2. Infection with certain viruses or toxoplasma in early pregnancy.

3. Androgen insensitivity syndrome or chromosomal abnormalities.

The main goal of congenital absence of vagina treatment is to reconstruct the vagina to solve the patient's sexual life problems. Non-surgical and surgical methods can be used. There are many types of surgical procedures, each with its own advantages and disadvantages. The ideal vaginoplasty should be to minimize the damage to the patient and reconstruct a vagina that is close to normal in both anatomy and function.