How to treat hyperprolactinemia

Hyperprolactinemia is a common disease among women, which brings a lot of harm to female friends. Hyperprolactinemia should be treated actively. What are the causes of hyperprolactinemia? How to treat hyperprolactinemia? This is a problem that most female friends do not understand. Let's take a look at it together.

Treatment of the cause and underlying disorder

Such as eliminating adverse mental stimulation, stopping the use of HPRL-inducing drugs, and actively treating primary diseases such as pituitary tumors, hypothyroidism, Cushing's disease, etc. Anti-prolactin-bromocriptine therapy

Bromocriptine is a semi-synthetic ergot alkaloid derivative and a dopamine receptor agonist. It can promote the synthesis and secretion of PRL-IH and inhibit the synthesis and release of PRL through the receptor mechanism. It also directly acts on pituitary tumors and PRL cells to curb tumor growth and inhibit the secretion of PRL, GH, TSH and ACTH.

Bromocriptine therapy is suitable for all types of HPRL and is also the first choice for pituitary adenomas (micro/macroadenomas), especially for young infertile women who are looking forward to having children. The dose is 2.5-7.5 mg/d, taken orally. Other anti-prolactin drugs include: levodopa, octahydrobenzoquinoline (cv205-502), vitamin b6, etc. For details, please refer to the anti-prolactin section in the endocrine therapy chapter.

Ovulation induction therapy

It is suitable for patients with HPRL, anovulatory infertility, and those who cannot successfully ovulate and become pregnant after simple bromocriptine treatment. That is, a comprehensive therapy with bromocriptine as the main drug and other ovulation-promoting drugs: ① bromocriptine-cc-hcg; ② bromocriptine-hmg-hcg; ③ gNRH. Pulse therapy-bromocriptine, etc. Comprehensive therapy can save anti-prolactin, shorten the treatment cycle and increase the ovulation rate and pregnancy rate.

Surgery

It is suitable for patients with giant adenomas that present compression symptoms, as well as patients with drug-resistant tumors, patients who are unresponsive to bromocriptine treatment, and patients with septicomas that secrete multiple pituitary hormones.

The current transsphenoidal microsurgery is safe, convenient, and easy to perform, and its efficacy is similar to that of bromocriptine therapy. The use of bromocriptine before and after surgery can improve the efficacy. The disadvantages of surgery are: if the pituitary tumor has no obvious capsule and unclear boundaries, the surgery is not easy to be thorough or may cause damage, resulting in cerebrospinal fluid nasal fistula and secondary hypopituitarism.

Radiation therapy

It is suitable for non-functional tumors of the HP system and those who have not responded to drug and surgical treatment. Irradiation methods include: deep X-ray, 60Co, α particles and proton rays. Isotope 90yttrium, 198gold pituitary implantation, etc.

After reading the above content, I think everyone must have understood the treatment of hyperprolactinemia. I hope everyone can pay attention to this disease. If you find any signs of hyperprolactinemia, you must go to the hospital for diagnosis and active treatment.