Pituitary function tests for amenorrhea

There are many examination methods for patients with amenorrhea, such as uterine examination, ovarian function examination and pituitary function examination. The pituitary function examination methods are as follows:

Measure the levels of follicle stimulating hormone and luteinizing hormone in the blood

Because the secretion of follicle-stimulating hormone and luteinizing hormone in the blood is pulsatile, it can be repeatedly checked and evaluated. The normal range of follicle-stimulating hormone is: 5-40IU/L; luteinizing hormone is: 5-25IU/L. If the follicle-stimulating hormone and luteinizing hormone are both lower than the normal level, it means that the pituitary function or higher central function is low. If it is higher than the normal level, it indicates insufficient ovarian function.

Pituitary stimulation test

Dissolve 50 μg of luteinizing hormone-releasing hormone in 5 ml of normal saline and inject it intravenously. Take 2 ml of blood before injection and 15 minutes, 30 minutes, 60 minutes and 120 minutes after injection. Use radioimmunoassay to measure changes in blood luteinizing hormone content. Generally, luteinizing hormone values ​​15-30 minutes after injection are about 2-4 times higher than those before injection, indicating that the pituitary function is good. If there is no increase or a slight increase, it means that the lesion may be in the pituitary.

Blood prolactin measurement

The normal value during non-pregnancy is 0-20μg/L. It is best to draw blood around 9 am.

Other tests

Sella X-ray, CT, MRI and other examinations can exclude pituitary tumors.

Tips: Patients with amenorrhea generally undergo a gynecological examination first, that is, a vaginal or anal examination, paying attention to the development of the vulva, the distribution of pubic hair, whether there is clitoral hypertrophy, the development of the vagina and uterus, whether there are congenital malformations, whether there are tumors and inflammation in the bilateral adnexa, etc.