Will vulvar leukoplakia develop into vulvar cancer?

Short story: Ms. Lin suffers from vulvar leukoplakia and vulvar itching for 15 years. She was diagnosed with chronic vulvar malnutrition type vulvar leukoplakia by a doctor. Ms. Lin is 54 years old and has been in menopause for 4 years. She found a lump on the left side of her vulva for half a year, and it gradually increased. Recently, the surface of the lump ulcerated and the pain worsened. She went to the hospital for examination: the skin and mucous membranes of the labia majora and labia minora of the vulva were discolored and white, and there was a 2×2×1cm lump between the labia minora and labia majora on the left side, which was brittle and ulcerated on the surface. There was a 1×1×0.8cm lump on the right labia minora. The two lumps were obviously tender, and a biopsy was taken from the lumps. The pathological diagnosis was vulvar squamous cell carcinoma.

Story analysis: Leukoplakia vulvae often occurs in middle-aged women before the age of 50, while the incidence in elderly women is lower. The most common clinical symptom of patients is vulvar itching, which is unbearable for most patients. The lesions of patients with leukoplakia vulvae are mostly located in the labia majora, interlabial groove and posterior perineal joint.

Ms. Lin developed vulvar cancer due to chronic vulvar malnutrition. The main factor for the development of vulvar cancer is squamous cell hyperplasia in vulvar leukoplakia, which is a predisposing factor for vulvar cancer. The probability of vulvar leukoplakia developing into vulvar cancer is 5% to 10%. Patients should receive timely treatment. If nodules appear in the affected area or the disease is not cured for a long time, the probability of developing into vulvar cancer increases.