High-dose progestogen for the treatment of dysfunctional uterine bleeding

High-dose progestin hemostasis is suitable for patients of all ages and types of functional uterine bleeding. The treatment principle is to promote synchronous endometrial secretion and stop bleeding. After stopping the drug, centralized withdrawal bleeding occurs. There are several methods:

oral

Norethindrone 5.0-7.5mg, or megestrol acetate, medroxyprogesterone acetate 8-10mg. Take once every 4-6 hours. After 3-4 oral administrations (24-36 hours), the bleeding stops, and the dose is changed to once every 8 hours. Then the dose is reduced by 1/3 every 3 days to the maintenance dose. Norethindrone 2.5-5.0mg/d, or megestrol acetate, medroxyprogesterone acetate 4-6mg/d, stop taking the drug 20 days after the hemostasis. To prevent breakthrough bleeding, a small dose of estrogen such as ethotripsy 0.25-0.5mg/d can also be taken in the evening. Menstrual regulation treatment starts on the fifth day of withdrawal bleeding.

Intramuscular injection

One intramuscular injection of compound progesterone acetate (250mg progesterone acetate + 5mg/Amp estradiol valerate) will stop bleeding in 1-2 days. Another intramuscular injection of compound progesterone acetate on the seventh to tenth day will complete one cycle of treatment. To speed up hemostasis, 2mg of estradiol benzoate or one compound progesterone (20mg progesterone + 2mg/Amp estradiol benzoate) can also be added. After hemostasis, one compound progesterone is injected every week, and 3-4 times to complete one cycle of treatment. Menstrual regulation treatment begins on the fifth day of withdrawal bleeding.

Medical curettage

It is suitable for those who have a small amount of spotting bleeding and have not had a large amount of bleeding recently. The principle is to use progesterone to secrete the endometrium in a short period of time and withdraw it in a concentrated manner. Method: Progesterone 20mg/dX3~5 days, concentrated withdrawal bleeding will stop naturally 3~5 days after stopping the drug. In order to reduce the amount of bleeding, testosterone propionate 25~50mg/d is also used at the same time. Or use three hormones 1 bottle/dX3 days for drug curettage. Start menstruation regulation treatment from the fifth day of withdrawal bleeding.