Analyzing the most common causes of uterine fibroids

Clinically, gynecological diseases are a type of disease with a high incidence rate. Many female friends are troubled by the frequent occurrence of various gynecological diseases. Uterine fibroids are one of the more common ones, which have a great impact on women's health. What are the common causes of uterine fibroids ? The following is a brief introduction to the causes of uterine fibroids.

In general, the common causes of uterine fibroids are:

In recent years, along with the research related to uterine fibroids and endocrine, experiments have confirmed that fibroid tissue has estrogen receptors (ER) and progesterone receptors (PR), and their density exceeds that of surrounding normal muscle tissue. ER and PR change with the menstrual cycle. There are reports that uterine fibroids increase in size after the use of exogenous hormones and clomiphene. Inhibiting or lowering sex hormone levels can prevent fibroid growth, shrink fibroids, and improve clinical symptoms, indicating that fibroids are sex hormone-dependent tumors. Antagonistic hormone drugs can be used to treat fibroids, but clinical measurements of peripheral blood sex hormones in patients with fibroids and women without fibroids show no significant difference. This is a common cause of uterine fibroids.

The cause of uterine fibroids is not so much related to the hormonal environment of the fibroid patient as it is to the abnormal local endocrine environment of the fibroid itself. For example, the estrogen concentration in fibroids is higher than that in uterine fibroids; the endometrial hyperplasia near fibroids is high, which are common causes of uterine fibroids. The same is true for receptors. The content of E (estradiol receptor) and PR in fibroids is higher than that in uterine fibroids.

From the perspective of tissue development, it has long been known that uterine fibroid cells originate from smooth muscle cells of the uterine muscle and blood vessel wall, such as immature myoblasts, but the latter has not yet been clearly defined in histology. Histological studies have found that small uterine fibroids that have not grown for a long time not only have mature smooth muscle cells rich in myofilaments, but also immature smooth muscle cells found in the fetal uterus. This indicates that the cause of uterine fibroids may come from the differentiation process of undifferentiated mesenchymal cells into smooth muscle cells.

The above analysis is the common cause of uterine fibroids. I believe everyone should have some understanding of this. If you still have questions about the cause of uterine fibroids, you can consult our online experts, who will give you detailed answers.