There are many causes of primary dysmenorrhea.

What is the cause of primary dysmenorrhea? Primary dysmenorrhea is seen in endometrial cast shedding, uterine flexion, uterine hypoplasia, cervical stenosis and other conditions. So, how is primary dysmenorrhea formed? Today, we invite an expert to tell us in detail the causes of primary dysmenorrhea.

The causes of primary dysmenorrhea are very complex, mainly:

Autologous hormone factors. Primary dysmenorrhea often occurs in the ovulatory menstrual cycle, indicating that primary dysmenorrhea is related to the release of autologous hormones after ovulation. The content of PGs in the endometrium also changes periodically. The concentration of PGFa gradually increases from the endometrial proliferation phase to the secretory phase, reaching a peak during the menstrual period. Adolescent girls do not ovulate and do not have dysmenorrhea. At this time, the PCs content is only 1/5 of that in the ovulation cycle; after taking oral contraceptives, the amount of PGs in menstrual blood drops below normal levels. These phenomena indicate that ovarian hormone imbalance can affect the synthesis of D in the endometrium and cause dysmenorrhea.

Vasopressin (AVP) factor. It is known that vasopressin containing arginine can cause strong contraction of the uterus of non-pregnant women, and the local blood flow decreases significantly. The plasma concentration of AVP and the responsiveness of the uterus to it vary with the menstrual cycle. It is most sensitive at the beginning of menstruation. The plasma AVP concentration of patients with primary dysmenorrhea on the first day of the menstrual cycle is significantly increased, which is 1-4 times that of the control group. In addition, the use of desaminoethyl oxytocin to competitively inhibit the effect of AVP on the uterus can significantly relieve the symptoms of primary dysmenorrhea. Therefore, AVP may also be an important cause of primary dysmenorrhea.

Mental factors. Dysmenorrhea often occurs in women with immature psychological development and neurotic personalities. Some girls do not have enough knowledge of menstrual physiology and feel fear and anxiety when their period is approaching. Unfavorable stimuli such as stressful study and work, sudden changes in the environment, and unhappy mood can all cause dysmenorrhea through the hypothalamus-pituitary-ovarian axis, leading to changes in hormones in the body. However, studies in recent years have shown that it is difficult to attribute dysmenorrhea to mental factors, and mental factors can have a certain impact on acute and chronic pain in any part of the body. It has no more unique effects on primary dysmenorrhea, so this factor has not been taken seriously.

Prostaglandins (PGs) have been studied and found that patients with dysmenorrhea have increased uterine cavity pressure, increased contraction frequency, uncoordinated contractions and rhythm disorders, which lead to reduced uterine blood flow and hypoxia, causing severe pain in patients. When 250 ug of B2 receptor agonist salbutamol was injected intravenously, uterine contractions disappeared, local blood flow improved significantly, and pain was completely relieved. This shows that primary dysmenorrhea is caused by excessive uterine contraction causing myometrial ischemia.

The above is the introduction of "Causes of Primary Dysmenorrhea", for reference only. Expert Tips: There are many causes of primary dysmenorrhea, and we should pay more attention to avoid primary dysmenorrhea from harming women's bodies. If you have other questions about the causes of primary dysmenorrhea, please consult our online experts for more information.

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