What are the causes of polyovarian cyst syndrome?

Polycystic ovary syndrome (PCOS) is a syndrome characterized by oligomenorrhea or amenorrhea, infertility, obesity, acne, hirsutism, and increased ovarian cysts.

What is the cause of polyovarian cystic syndrome?

Causes of polyovarian syndrome include:

1. Abnormal adrenal cortex function: It can cause abnormal relationship and secretion of the hypothalamic pituitary-ovarian axis. Some women with polycystic ovary have increased adrenal secretion of androgen, which may be due to abnormal regulation of the adrenal cortex P450c17 enzyme complex, blocking the biosynthesis of steroid hormones from 17-hydroxyprogesterone to estrone without enzyme.

2. Genetic factors: Some people think that this symptom is a hereditary disease, and it is also a sex-dominant inheritance method. Most women have a normal 46, XX karyotype. Chromosome abnormalities can be manifested as X deficiency or lack of the long arm of the chromosome X mosaicism, chromosome number and structural abnormalities.

3. High prolactin: About 20% to 30% of women with polycystic ovary also have hyperprolactinemia. Some people believe that PRL can stimulate the adrenal cortex cells to secrete PRL receptors because there is an androgen on the adrenal cortex cell membrane.

4. Abnormal ovarian regulatory mechanism: It is inferred that the follicles of women with polycystic ovary contain substances such as epidermal growth factor, transforming growth factor, and inhibin, which inhibit the sensitivity of granulosa cells to FSH and increase their own sensitivity. The FSH threshold further hinders the selection and development of dominant follicles.

5. Hypothalamic-pituitary dysfunction: In women with polycystic ovary, the LH/FSH ratio is greater than three. LH hypothalamic-pituitary dysfunction is the main factor for the onset of the disease and the main factor for hormonal abnormalities and anovulation.