Is obesity the cause of endometrial thickening?

The uterus is the cradle for women to give birth to babies. Like all organs in the body, the uterus is susceptible to diseases. Severe cases include malignant lesions such as uterine fibroids. Now let's take a look at one of the uterine diseases, endometrial thickening, also known as endometrial hyperplasia.

Endometrial thickening, also known as endometrial hyperplasia, refers to a disease in which the endometrium grows excessively due to endocrine disorders, inflammation, or certain drugs. Endometrial hyperplasia can occur at different ages, such as adolescence, reproductive period, menstruation, or postmenopause, but generally, women in adolescence or menopause who have irregular menstruation will have this disease. Especially for elderly patients with severe hyperplasia, the possibility of cancer should be guarded against. It is a reversible endocrine system disease, not an untreatable malignant disease. Therefore, as long as the majority of patients maintain a continuous benign state, they can be cured after active treatment.

Endometrial hyperplasia may also be a normal phenomenon

The endometrium is a layer of the uterine lining that responds to both estrogen and progesterone, and therefore can change significantly with the sex cycle. During the ovarian cycle, when mature, under the action of estrogen produced in the ovaries, the blood transport rate of the endometrium will increase and gradually thicken, that is, the thickness of the endometrium will increase, providing good conditions for the implantation of the fertilized egg and the development of the embryo.

What are the causes of abnormal endometrial thickening?

Disorders in ovarian hormone function lead to abnormal thickening of the endometrium. Large amounts of estrogen stimulate the endometrium to thicken it, which may lead to endometrial cancer. Therefore, endometrial hyperplasia rarely occurs in women with normal menstrual cycles. The specific reasons are as follows:

1. Improper use of contraceptives. Women who need contraception use progestin-free pills or hormone supplements, which may cause estrogen disorders in the body, lead to ovarian dysfunction, and long-term thickening of the endometrium. In addition, long-term use of tonics and health products containing a large amount of estrogen by women can also have adverse stimulation on the endometrium.

2. Chronic diseases. Mainly refers to patients with anovulation, such as polycystic ovary disease. Generally, they are young women of childbearing age.

3. Obese people. Experts say that fat is one of the main sources of estrogen for obese women. Because there is more fat tissue, the stronger the conversion ability is, the higher the level of estrogen in the body's plasma will be, so it will cause persistent high estrogen. The specific process is that androstenedione secreted by the adrenal glands is converted into estrone by aromatase in adipose tissue, which continuously stimulates the endometrium and leads to hyperplasia..

4. Endocrine function tumors. Ovarian granulosa cell tumors can continuously secrete estrogen. Ovarian granulosa cell tumors can continuously secrete estrogen. Endocrine function tumors are rare tumors that cause abnormal pituitary gonadotropin function.