Symptoms of hyperprolactinemia

Hyperprolactinemia refers to a syndrome caused by internal and external environmental factors, characterized by elevated prolactin (PRL) (>25ng/ml), amenorrhea, galactorrhea, anovulation and infertility. It is now a common disease, and if you want to treat it effectively, you need to understand the common symptoms of the disease.

Symptoms of hyperprolactinemia

1. Menstrual disorders : primary amenorrhea accounts for 4%, secondary amenorrhea accounts for 89%, oligomenorrhea and oligomenorrhea account for 7%, and dysfunctional bleeding and luteal insufficiency account for about 50%.

2. Galactorrhea The incidence of typical amenorrhea-galactorrhea syndrome is 20% in non-tumor hyperprolactinemia, 70% in tumor-type, and 80% in simple galactorrhea. Galactorrhea is overt or occurs when the breast is squeezed, and is watery, serous, or milky. The breasts are usually normal.

3. The incidence of infertility is 75% , which can be primary or secondary infertility and is related to anovulation, luteal insufficiency or luteinized unruptured follicle syndrome (LUFS).

4. Hypoestrogenemia and hyperandrogenism : Decreased estrogen causes hot flashes, palpitations, spontaneous sweating, vaginal dryness, dyspareunia, decreased libido, etc. Increased androgen causes moderate obesity, seborrheic dermatitis, acne, and hirsutism.

5. Changes in vision and visual field: When pituitary tumors involve the optic chiasm, it can cause decreased vision, headache, dizziness, hemianopsia and blindness, as well as functional damage to cranial nerves II, III, and IV, and fundus edema and exudation.

6. Acromegaly : seen in PRL-GH adenoma, myxedema seen in combined hypothyroidism, some patients have type 2 diabetes and osteoporosis.