How to treat infertility caused by hyperprolactinemia

There are many reasons for hyperprolactinemia, but patients with hyperprolactinemia should pay attention to maintaining good living habits, which is the key to preventing hyperprolactinemia. However, they should also pay attention to treatment and have good and lasting treatment methods. What are the treatments for hyperprolactinemia?

The treatments for hyperprolactinemia are as follows, usually five. The first thing I recommend is the treatment of the cause and primary disease, such as eliminating adverse mental stimulation, stopping the use of HPRL-causing drugs, and actively treating primary diseases such as pituitary tumors, hypothyroidism, Cushing's disease, etc. Secondly, anti-prolactin-bromocriptine therapy. Bromocriptine is a semi-synthetic ergot alkaloid derivative, a dopamine receptor agonist, which can promote the synthesis and secretion of PRL-IH and inhibit the synthesis and release of PRL through receptor mechanism, and directly act on pituitary tumors and PRL cells to curb tumor growth and inhibit the secretion of PRL, GH, TSH and ACTH.

The more you know about the treatment of hyperprolactinemia, the better. Ovulation induction therapy is suitable for HPRL, anovulatory infertility, and those who cannot successfully ovulate and become pregnant with bromocriptine alone. That is, a comprehensive therapy with bromocriptine as the main drug and other ovulation induction drugs: ① bromocriptine-CC-hCG; ② bromocriptine-hMG-hCG; ③ GnRH. Pulse therapy-bromocriptine, etc. Comprehensive therapy can save anti-prolactin, shorten the treatment cycle and increase the ovulation rate and pregnancy rate. Surgical therapy is a commonly used treatment for hyperprolactinemia. It is suitable for patients with compression symptoms of giant adenomas, as well as patients with tumor resistance, bromocriptine treatment failure, and multiple pituitary hormone secretion of sphenoid cell tumors. The current transsphenoidal microsurgery is safe, convenient, and easy to perform, and its efficacy is similar to that of bromocriptine therapy. The combination of bromocriptine before and after surgery can improve the efficacy. The disadvantages of surgery are: if the pituitary tumor has no obvious capsule and unclear boundaries, the surgery is not easy to be thorough or may cause damage, resulting in cerebrospinal fluid nasal fistula and secondary pituitary function deficiency.

Radiotherapy is also a commonly used treatment method, suitable for non-functional tumors of the HP system and those who are ineffective with drug and surgical treatment. Irradiation methods include: deep X-rays, 60Co, α particles and proton rays. Isotope 90 yttrium, 198 gold pituitary implants, etc.

Hyperprolactinemia often occurs in our lives. The occurrence of hyperprolactinemia will have a great impact on the patient's physical and mental health. If we don’t know the symptoms of hyperprolactinemia, it will cause a lot of harm to patients with hyperprolactinemia, and we may miss the best time for treatment, which will cause greater harm to patients.