Why is it more common to get vaginitis during pregnancy? Can medication be used to treat it?

Why is vaginitis more likely to occur during pregnancy? Can medication be used to treat it?

This is related to the physical changes during pregnancy:

1. Hormonal changes: During pregnancy, the levels of estrogen, progesterone, prolactin and adrenal cortex hormone in women are higher than those in the non-pregnant period, which increases the glycogen content in the vaginal epithelium and increases vaginal secretions.

2. Decreased resistance: Pregnancy is the time when women’s resistance is the weakest, and the self-cleaning ability of the vagina and urethra will also be reduced.

3. Vaginal and urethral congestion: During pregnancy, the vaginal and urethral mucosa will be slightly congested and prone to minor injuries, which can also lead to the proliferation of bacteria in the urethral opening, vagina and surrounding areas.

4. Changes in the urinary system: Some changes in the urinary system during pregnancy are also conducive to bacterial reproduction.

Why is vaginitis more likely to occur during pregnancy? Can medication be used to treat it?

The most common vaginitis during pregnancy is vulvovaginal candidiasis and Trichomonas vaginitis:

Oral medications have the risk of causing fetal malformations, so local treatment is best. Suppositories can also be used for local treatment in the second and third trimesters.

① Metronidazole

It has a powerful effect of killing trichomonas without affecting the growth of normal vaginal bacteria and is the first choice drug for the treatment of vaginal trichomoniasis.

The mechanism of action of metronidazole against anaerobic bacteria is that the nitro group of the drug can be reduced by anaerobic bacteria to produce cytotoxic substances, which inhibit the DNA of sensitive bacteria and cause bacterial death.

② Nystatin vaginal suppository

This product has certain effects on Candida albicans, Cryptococcus neoformans, Histoplasma capsulatum, Coccidioides, Microsporum, Trichophyton, Epidermophyton, etc., and also has a killing effect on Trichomonas vaginalis.

③Nifuratel Nystatin Vaginal Soft Capsules

A combination of nivolumab and nystatin.

Nifuratel is a furan derivative with strong bactericidal and trichomonascidal activity, and also has certain antifungal effects.