Salvia miltiorrhiza, a traditional Chinese medicine for weight loss! Mouse experiment: Can inhibit white fat and reduce weight safely

Obesity is the root of all diseases. In addition to diet control and regular exercise, the Chinese herbal medicine Salvia miltiorrhiza may also be able to help in the future. According to research conducted by the Taipei Medical University and Hualien Tzu Chi medical team, in animal experiments, Salvia miltiorrhiza, which has the function of replenishing blood and activating blood circulation, can inhibit white fat in body fat and can safely and effectively control weight.

Danshen, which has the function of nourishing blood and activating blood circulation, has been found in animal experiments to be effective in reducing body fat.

According to data from the World Health Organization, approximately 13% of the world's population suffers from obesity. According to statistics from the National Health Administration, the prevalence of overweight and obesity among adults in Taiwan (body mass index greater than or equal to 24) is 45.4%. Lin Heng, director of the doctoral program in technical medical industry research and development at Taipei Medical University, said that obesity caused by excessive body fat will also increase the risk of cardiovascular disease and diabetes.

Chinese medicine Danshen can inhibit white fat

But in fact, there are differences in fat cells. The white fat that mainly causes obesity has a large oil droplet that stores energy, while the brown fat contains many mitochondria that can absorb glucose and triglycerides in the blood, burn the oil droplets, consume energy, and achieve the effect of weight loss.

Unlike white fat distributed under the skin and in the internal organs, which is responsible for storing energy, brown fat can convert energy, effectively burn fat and generate heat energy. However, the amount of brown fat in the adult body is quite rare. Therefore, how to increase the amount of brown fat and thereby enhance fat burning is considered one of the important research directions.

The research team is actively seeking corporate cooperation, hoping to use ST32da to replace clenbuterol and open up another blue ocean in the biotechnology industry.

Mouse experiment effectively removes oil and reduces body fat

Director Lin Heng pointed out that this research was conducted in collaboration between the National Taipei Medical University and Dr. Zheng Jingfeng of Hualien Tzu Chi Hospital. The research team used the gene screening platform transferred from Academia Sinica technology and discovered that ST32da, a single compound extract of Salvia miltiorrhiza, could effectively inhibit white mitochondria in body fat among more than 200 Chinese herbal medicines.

The team members conducted a 16-week animal experiment on mice and compared them with legal domestic weight-loss drugs on the market. The results showed that after the administration of ST32da, the white fat in the mice's bodies was successfully converted into brown fat, which not only inhibited weight gain, but also showed a downward trend in body fat percentage. It is worth noting that the mice's hearts, livers, and kidneys did not have any problems, and even reduced the liver inflammation index. The weight-loss drugs that are popular in the market that can excrete oil not only cause inconvenience to people's lives, but also found in mouse experiments that the drugs encountered a stagnation period after entering the 12th week.

Slimming patch industry-university-creation biotechnology blue ocean

Director Lin Heng emphasized that the team has high hopes that this single compound can help improve the global obesity problem. In the future, in addition to being able to be further developed into oral weight loss products, it can also be developed into weight loss patches for local parts of the body. What is even more exciting is that in mouse experiments, ST32d also has a positive effect on improving diabetes, and cell experiments have also proven that it can inhibit the formation of fatty liver.

In addition, Dr. Zheng Jingfeng from the Department of Pediatrics at Hualien Tzu Chi Hospital also emphasized that this mouse experiment also found that high doses of Salvia miltiorrhiza extract ST32da can significantly improve abdominal fat, while low doses can reduce body fat overall. This research will be published in a foreign medical journal in the near future. At the same time, the research team will actively seek corporate cooperation in the future and plans to use pigs for animal experiments, hoping to use ST32da to replace clenbuterol and open up another blue ocean in the biotechnology industry.