Do you know about ovarian hyperprolactinemia?

Do you know about ovarian hyperprolactinemia? During examinations in the hospital, some patients are diagnosed with infertility caused by hyperprolactinemia. Many patients do not know what this disease is. So, what is hyperprolactinemia? Hyperprolactinemia is a series of diseases caused by abnormal hormone levels.

Hyperprolactinemia (HPRL) is a condition in which the level of peripheral serum prolactin (PRL) is continuously higher than the normal value due to various reasons. It is usually considered that in normal women of childbearing age, the serum value must be >25-30t/g/L at least twice in strict accordance with the requirements before it can be diagnosed. So, what is hyperprolactinemia? The following is an introduction by an expert.

Hyperprolactinemia is the most common hypothalamic-pituitary-gonadal axis dysfunction disease in young women. The incidence of hyperprolactinemia in different test populations is reported differently. In the unselected normal population, about 0.4% of people suffer from hyperprolactinemia; in the family planning clinic population, the incidence of hyperprolactinemia is 5%. In patients with simple amenorrhea, about 15% have hyperprolactinemia. In patients with amenorrhea and galactorrhea, about 70% have hyperprolactinemia. 15% of anovulatory women also suffer from hyperprolactinemia, and 43% of anovulatory women with galactorrhea have hyperprolactinemia. 3% to 10% of anovulatory polycystic ovary patients have hyperprolactinemia.

There are few reports on the incidence of hyperprolactinemia in infertile patients. During stress, the pituitary gland releases stress hormones including PRL, adrenocorticotropic hormone (ACTH), and growth hormone (GH). Stress can increase the level of PRL in the human body by 2 to 3 times, but the duration is less than 1 hour.

Pituitary adenoma is a common functional intracranial tumor, accounting for 10%-is% of all intracranial tumors. PRL adenoma is the most common pituitary adenoma, accounting for about 45% of all pituitary adenomas, and is the most common cause of pathological hyperprolactinemia in clinical practice. PRL adenomas are mostly benign tumors, which can be divided into microadenomas (10mm) according to their size. In general, the annual incidence of PRL tumors is 6/1 million to 19/1 million, and the prevalence is 6011 million to 100/1 million. Recent studies have shown that the overall prevalence of PRL tumors may be far more than this, and may increase by 3 to 5 times on this basis.

To confirm the disease, at least two hormone level tests are required. It is impossible to determine whether it is the disease through one test because hormone levels are prone to change. If it is necessary to determine whether it is a lesion, multiple tests must be conducted. This must be paid attention to. In addition, the cause of the disease must be clarified and scientific treatment must be carried out in a regular hospital to ensure that it does not affect fertility.