Overview of basic knowledge of hyperprolactinemia

How can a woman be charming when she is sick, especially when she suffers from hyperprolactinemia? Women suffer from symptoms such as pain and cough, and they are under great mental torture. Therefore, everyone must recognize this disease as early as possible and make correct diagnosis and treatment. The following is an overview of the basic knowledge of hyperprolactinemia, I hope it will be helpful to everyone.

Hyperprolactinemia is the hormone with the most influencing factors and the largest fluctuation in serum levels among the anterior pituitary hormones. It refers to a syndrome characterized by persistently elevated prolactin levels in the blood, which is clinically characterized by hypogonadism and lactation. PRL is a stress hormone, and its serum level varies greatly under various physiological conditions and various stresses. Its normal secretion is pulsatile. Like other anterior pituitary hormones, it changes periodically with sleep-wakefulness, gradually increasing after falling asleep, reaching a peak about 1 hour before waking up, and gradually decreasing after waking up, so the secretion during the day is lower than at night. Using labeled immunoassay, normal females have a level of 1-25 ng/ml, and males have a level of 1-20 ng/ml.

Different treatment measures should be formulated for different causes. Patients with hypothyroidism need to use L-thyroxine replacement therapy. Heterologous PRL secretion should be directed at the primary tumor. For the treatment of pituitary tumors and PRL tumors, please refer to the relevant chapters. For drug-induced diseases, stop using related drugs. Patients with high RPLemia and hypogonadism for 1 to 2 years, and those who cannot make a definite diagnosis of pituitary lesions by imaging examinations, can be treated with bromocriptine to inhibit PRL secretion and restore gonadal function. For female patients suspected of PRL tumors, estrogen is prohibited to prevent PRL tumors from growing. If clinical symptoms persist after stopping oral contraceptives for high PRLemia, gonadotropins or chlorpheniramine can be used to promote the complete recovery of the physiological function of the hypothalamus-pituitary-ovarian axis. Oral contraceptives can be used for lactational amenorrhea caused by postpartum.