How is the thickness of the endometrium formed?

Endometrial hyperplasia can occur at any age, during adolescence, reproductive period, perimenopause or postmenopause. Elderly patients over 40 years old with severe hyperplasia should be alert to the possibility of cancer. So what causes endometrial thickness? The following editor will introduce it to you in detail.

What is endometrial thickening?

Endometrial hyperplasia is thickening of the endometrium. Endometrial hyperplasia is also called precancerous lesions, which have a certain tendency to become cancerous. Endometrial hyperplasia is a reversible lesion and may develop into cancer. The vast majority of endometrial hyperplasia is a reversible lesion or maintains a persistent benign state. Only a few cases may develop into cancer after a long time interval. There are three types of endometrial hyperplasia: simple hyperplasia, complex hyperplasia and atypical hyperplasia.

Causes of endometrial thickening

If the ovarian hormones are disordered, it can easily lead to abnormal thickening of the endometrium, namely endometrial hyperplasia. The reason for the thickening of the endometrium is that a large amount of estrogen stimulates the endometrium.

Anovulation may occur in adolescent girls, perimenopausal women, disorders in a certain link of the hypothalamus-pituitary-ovarian axis, polycystic ovary syndrome, etc., causing the endometrium to be continuously affected by estrogen for a longer period of time, resulting in anovulation; in obese women, the more adipose tissue there is, the stronger the conversion ability is, and the higher the level of estrone in the plasma, resulting in continuous estrogen influence; the gonadotropin function of the pituitary gland is abnormal, and ovarian granulosa cell tumor is also a tumor that continuously secretes estrogen.

Most patients with endometrial hyperplasia develop endometrial hyperplasia during menopause or adolescence. The clinical manifestations are irregular and heavy abnormal uterine bleeding. Patients may experience continuous bleeding after a long period of amenorrhea, which may be suspected of miscarriage. It may also manifest as shortened cycles and prolonged menstruation, with bleeding time up to 1 month.