Can endometriosis be completely cured?

Regarding the treatment methods of endometriosis, it is necessary for everyone to actively understand it. Correct treatment is the wish of every patient, so everyone must pay attention to relevant treatment methods. Next, we will understand whether endometriosis can be cured and see which method is more suitable for you.

Treatments for endometriosis:

1. Danazol

It is a derivative of the synthetic steroid 17α-ethynyltestosterone. Its main function is to inhibit the production of hypothalamic GnRH, thereby reducing the synthesis and release of FSH and LH, leading to the inhibition of ovarian function. It can also directly inhibit the synthesis of ovarian steroid hormones or competitively bind to estrogen and progesterone receptors, thereby leading to atrophy of ectopic endometrium, anovulation and amenorrhea. Danazol also has a mild androgenic effect, producing masculine manifestations such as increased hair growth, deepening of the voice, smaller breasts and the appearance of acne. Another common side effect of danazol is water retention and weight gain. It should not be used by people with hypertension, heart disease or renal insufficiency. Danazol is mainly metabolized by the liver and may cause certain damage to liver cells, so it is contraindicated for women with liver disease.

The commonly used dose is 400 mg/d, taken orally 2 to 4 times, starting from menstruation. Generally, the symptoms will be relieved in about 1 month. If it is ineffective, it can be increased to 600 to 800 mg/d, and then gradually reduced to 400 mg/d after the effect is achieved. The course of treatment is generally 6 months, and 90 to 100% of patients achieve the effect of amenorrhea.

Danazol has a better effect on pelvic peritoneal endometriosis, but a poorer effect on ovarian ectopic masses larger than 1 cm in diameter.

2. Synthetic progesterone

Ethinyl isoprogesterone, norethindrone or medroxyprogesterone acetate (medroxyprogesterone acetate) can be used for cyclical treatment to degenerate the ectopic endometrium. From the sixth day of the menstrual cycle to the twenty-fifth day, take 5 to 10 mg of one of the above drugs orally every day. The course of treatment depends on the effect of the treatment. This method can inhibit ovulation. Therefore, for those who want to have children, 10 mg of ethinyl isoprogesterone or norethindrone can be used every day from the sixteenth day of the menstrual cycle to the twenty-fifth day. This can control endometriosis without affecting ovulation. Some cases have more serious side effects during the treatment period, such as nausea, vomiting, headache and swelling, uterine cramps, breast pain, and excessive weight gain due to water retention and improved appetite. Sedatives, antiemetics, diuretics and low-salt diet can alleviate them.

3. Gonadotropin-releasing hormone agonist (GnRHa)

In 1982, Meldtum and Lemay reported that the use of LHRHa to treat endometriosis achieved good results. LHRH has a biphasic effect on the pituitary gland. The continuous use of LHRH in large quantities causes pituitary cells to downregulate, that is, the pituitary cell receptors are filled with hormones and cannot synthesize and release FSH and LH, which plays a counter-regulatory role. Side effects include hot flashes, vaginal dryness, headaches, and a small amount of vaginal bleeding.

4. Nemestran

That is, 3-enoylgostyrone (R2323), a 19-nortestosterone derivative, has high anti-progestin activity and moderate anti-estrogen effect, inhibits the secretion of FSH and LH, reduces the estrogen level in the body, and causes the ectopic endometrium to shrink and absorb.

To sum up, the above content talks about the hormonal treatment of endometriosis, which can enable women to better treat endometriosis. Patients with endometriosis should also choose appropriate drug treatment, and eat more vegetables and fruits to keep a good mood.

The treatment method of endometriosis is an issue that patients cannot ignore. Only correct treatment can be beneficial to the treatment of the disease. Of course, under the premise of correct treatment, everyone must actively consult relevant experts to help everyone come up with accurate treatment methods and avoid unnecessary harm to the greatest extent.