How to check for premature ovarian failure

How to check for premature ovarian failure?

Premature ovarian failure examinations are mainly diagnosed through chromosome examinations, central nervous system examinations, autoinfectious disease screening, ultrasound examinations, and laparoscopy. Some women have symptoms of premature ovarian failure, and these subtle changes may be manifestations of physical illness, so they should be checked in time.

1. Chromosome examination: exclude ovarian failure caused by chromosomal abnormalities.

2. Screening for autonomic nervous system diseases: adrenal function; cortisol; ACTH; thyroid function: T3, T4, TSH; diabetes: fasting blood sugar; autoantibodies: antinuclear antibodies, antithyroglobulin antibodies, antithyroid granular antibodies, anticardiolipin antibodies, rheumatoid factor, etc. Routine blood tests, red blood cell sedimentation and urine tests should also be performed.

3. Central nervous system examination: When POF is combined with central nervous system symptoms, pituitary magnetic resonance imaging should be performed to eliminate the pituitary gland, which is a common measure for detecting premature ovarian failure.

4. Bone density measurement: Common methods include dual-energy X-ray absorptiometry, single photon absorptiometry, quantitative CT and ultrasound. Osteoporosis can be diagnosed by referring to normal bone density values.

5. Laparoscopy: Check for ovarian atrophy or atypical hyperplasia. Ovarian biopsy and ovarian interstitial fibrosis, primordial follicles 0-1/HP, biopsy is generally not recommended.

6. Ultrasound examination: It can effectively detect premature ovarian failure. Ovarian capacity reflects the state of the ovaries and changes before FSH rises. Pelvic ultrasound of most patients with premature ovarian failure shows reduced ovaries and uterus, and no follicles in the ovaries, but more than one-third of patients with normal ovarian hypoplasia may have follicles.

7. Hormone level check: a decrease in hormone levels in the body can lead to a decrease in female fertility, further decline in ovarian function, gradual atrophy of the reproductive organs, and ultimately premature ovarian failure.