Causes of premature ovarian failure

Causes of premature ovarian failure:

Most of them may be related to genetics, gonadal dysgenesis, endocrine and immune diseases. Some patients with premature ovarian failure may also suffer from autoimmune endocrine diseases, such as adrenal insufficiency, diabetes, hyperthyroidism or hypothyroidism, which can lead to premature ovarian failure.

1. Genetic factors

Genetic factors account for 100%; it is one of the important factors of premature ovarian failure;

2. External factors

External factors that have a certain impact on ovarian function, such as radiotherapy, chemotherapy, immunosuppressants and surgery;

3. Reproductive factors

Fertility can reduce the risk of premature menopause in nulliparous women with POF, which is related to the number of births and long-term menstrual disorders. Multiple miscarriages also increase the risk of POF;

4. Psychosocial factors

Strong mental stimulation, such as long-term anxiety, depression, sadness, anger, fear and other sudden changes in living environment, can stimulate the central nervous system and seriously affect ovarian function;

5. Living environment factors

Environmental toxins such as PAHs and nicotine in cigarettes can damage follicles and harm human reproductive function;

6. Excessive weight loss

Excessive weight loss in women can lead to a sharp drop in body fat. If the fat rate is too low, it will affect the estrogen level in the body, because the main raw material for synthesizing estrogen is fat. When the body fat is insufficient, it will lead to estrogen deficiency. Once the estrogen decreases, it will lead to menstrual disorders, severe or even amenorrhea. Then it will affect the ovarian function and cause the ovaries to decline prematurely.

7. Infection factors

Children and adolescents with viral mumps oophoritis, varicella virus, cytomegalovirus infection, and severe pelvic tuberculosis, gonorrhea, and suppurative pelvic inflammatory disease may suffer from partial or complete loss of ovarian function.