What is uterine fibroids? How are uterine fibroids formed?

Uterine fibroid cells are located on the blood vessel wall, and uterine smooth muscle cells are like immature myoblasts, but there is no clear concept in medical histology. Female uterine fibroid products may be due to the proliferation and differentiation process of undifferentiated mesenchymal cells to smooth muscle cells. Experts have found that uterine fibroids are one of the most common benign tumors in gynecology, and the cause is still unclear.

Multiple uterine fibroids may be caused by the origin cells lurking in the myometrium. After entering sexual maturity, the undifferentiated mesenchymal cells and mature smooth muscle cells remaining in the myometrium undergo their own continuous proliferation, differentiation and hypertrophy process under the action of the estrogen and progesterone cycle, which is repeated for a long time and eventually forms a tumor. However, according to long-term observations, it is still related to the patient's estrogen. During pregnancy and in the case of exogenous high estrogen, female friends are more likely to develop uterine fibroids.

The estrogen dependence of fibroids also includes receptors. According to long-term studies on the relationship between the patient's endocrine system and uterine fibroids, experiments have verified that fibroid tissue is composed of estrogen receptors (ER) and progesterone receptors (pR), and its density exceeds that of the surrounding normal muscle tissue. ER and pR change with the menstrual cycle. It is reported that the application of exogenous hormones and clomiphene after uterine fibroids will increase. Inhibiting or reducing sex hormone levels can prevent fibroid growth, reduce fibroids, and improve clinical symptoms, indicating that fibroids are sex hormone-dependent tumors. The application of antagonistic hormone drugs can treat fibroids, but there is no significant difference in blood sex hormones around fibroid patients and women without fibroids. It shows that the occurrence of fibroids is related to the abnormal local endocrine environment, rather than the hormonal environment of fibroid patients. If the estrogen concentration in the fibroid is higher than that in the uterine muscle; the endometrial hyperplasia is higher than that near the fibroid. The same is true for receptor status. The E2R (estradiol receptor) and pR of fibroids are higher than those of uterine muscles.

Small uterine fibroids that have not grown for a long time are not only rich in smooth muscle cells with mature myofilaments, but also immature smooth muscle cells seen in the fetal uterus are found. This indicates that the occurrence of uterine fibroids in women may come from the differentiation process of undifferentiated mesenchymal cells to smooth muscle cells. Multiple uterine fibroids may be due to the lurking of multiple origin cells in the myometrium. This undifferentiated mesenchymal cell is the original cell of the fibroid and is a cell with multiple differentiation functions in the embryonic period. It has biological media, depends on estrogen for proliferation, and depends on progesterone for differentiation and hypertrophy. After entering sexual maturity, undifferentiated mesenchymal cells and immature smooth muscle cells remain in the myometrium, and under the action of the estrogen and progesterone cycle, they appear to have their own continuity (self-perpetuating) before the formation of fibroids, and the process of proliferation, differentiation and hypertrophy is repeated for a long time.

The above is a detailed explanation of the cause of uterine fibroids by experts. Experts said that the pathogenesis of uterine fibroids is still related to the secretion of female estrogen. If women find that they are unwell, they should go to the hospital for examination in time to eliminate the harm of uterine fibroids.