Treatment of hypothalamic amenorrhea

Amenorrhea is a common symptom in women. Physiological amenorrhea is a normal physiological phenomenon that has nothing to do with disease and is basically harmless to health. Hypothalamic amenorrhea is one type of physiological amenorrhea and is also the most common cause of amenorrhea.

The hypothalamus secretes gonadotropin-releasing hormone, but hypothalamic amenorrhea is caused by mental factors, tension, fear, anxiety, environmental changes, regional migration, cold stimulation, malnutrition or chronic wasting diseases, long-term use of contraceptives, amenorrhea and lactation, polycystic ovary syndrome, etc. Due to the influence of various stimuli from inside and outside the body, the dysfunction between the central nervous system and the hypothalamus affects the function of the pituitary gland, among which luteinizing hormone is often affected, and ovulation function is impaired. When the degree of inhibition increases and follicle-stimulating hormone is affected, follicle development is impaired, and then amenorrhea occurs.

Inducing ovulation is one of the methods for treating hypothalamic amenorrhea. For patients who want to have children and have not lost their ovarian function, hormones or analogs can be used to induce ovulation:

1. For patients with pituitary insufficiency, follicle-stimulating hormone extracted from urine of postmenopausal women can be used to promote follicle development and secrete estrogen, and combined with chorionic gonadotropin for treatment, the success rate of ovulation is high;

2. For those with normal pituitary and ovarian functions but insufficient or uncoordinated hypothalamic function, clomiphene can be used to correct the function of the hypothalamic-pituitary-ovarian axis and induce ovulation.