Two common causes of primary dysmenorrhea

Primary dysmenorrhea is a very common gynecological disease that seriously affects women's health. What are the causes of primary dysmenorrhea ? Here are some common causes of primary dysmenorrhea.

In general, the common causes of primary dysmenorrhea are:

1. Prostaglandins (PGs) factors: Studies have found that patients with dysmenorrhea have increased uterine cavity pressure, increased contraction frequency, uncoordinated contractions, and rhythm disorders, which lead to reduced uterine blood flow and hypoxia, causing severe pain in patients. When patients were given an intravenous injection of 250 ug of the B2 receptor stimulant mesalbutamol, uterine contractions disappeared, local blood flow improved significantly, and pain was completely relieved. This shows that primary dysmenorrhea is caused by excessive uterine contraction causing myometrial ischemia.

The content of PGs in the endometrium and menstrual blood of patients with primary dysmenorrhea is significantly higher than that of women without dysmenorrhea. In recent years, primary dysmenorrhea tends to be related to excessive release of endometrium. Some people have measured the content of PGF2a in the endometrium of normal and primary dysmenorrhea women on the first day of menstruation. The average content of PGF2a in the endometrium of normal women is 4.5nmol/L (434pg/mL). The average content of PGF2a in the endometrium of patients with primary dysmenorrhea is 17.20nmol/L/, and the difference is extremely significant. The most PGs are released within 48 hours of menstrual blood, which is completely consistent with the time and duration of clinical spasmodic pain. The use of PGs synthesis inhibitors such as mefenamic acid, indole azole derivatives (indomethacin), benzoic acid derivatives (ibuprofen) and the like are effective in treating primary dysmenorrhea, which also illustrates this point.

2. Autohormone factors

Primary dysmenorrhea often occurs during the ovulatory menstrual cycle, indicating that primary dysmenorrhea is related to the release of autologous hormones after ovulation. The content of PGs in the endometrium also changes periodically, with the concentration of PGFa gradually increasing from the endometrial proliferation phase to the secretory phase, reaching a peak during the menstrual period. Adolescent girls do not ovulate or have dysmenorrhea, and their PCs content is only 1/5 of that in the ovulatory cycle; after taking oral contraceptives, the amount of PGs in menstrual blood drops below normal levels, indicating that ovarian hormone imbalance can affect the synthesis of D in the endometrium and cause primary dysmenorrhea.

The above is an introduction to the common causes of primary dysmenorrhea. I hope it will be helpful to everyone. Once you suffer from primary dysmenorrhea, you must go to the hospital for treatment in time to avoid delaying the condition.

For more information, please visit the dysmenorrhea disease special topic at http://www..com.cn/fuke/tongjing/ or consult an expert for free. The expert will then give a detailed answer based on the patient's specific situation.