Experts tell you the causes of uterine fibroids!

There is no consensus on the tissue origin of uterine fibroids. Some people believe that it is caused by the proliferation of immature uterine wall smooth muscle cells, while others believe that it is caused by the smooth muscle tissue of the uterine blood vessel wall. Let our experts briefly introduce the causes of uterine fibroids to you! I hope it will be helpful to you!

Experts on the causes of uterine fibroids introduce to you:

As early as the early 1970s, Townsend found through X-linked glucose-6-phosphate dehydrogenase (G6PD) isozyme analysis that the smooth muscle cells of randomly distributed different myomas from the same uterus all had exactly the same G6PD electrophoresis type, suggesting that these tumors originated from a single myoma smooth muscle cell, that is, each uterine myoma originated from a single cell. Multiple uterine myomas may be multi-source monoclonal tumors formed by multifocal latent cells in the myometrium. Histological studies have found that small uterine myomas that do not grow for a long time are not only rich in mature smooth muscle cells containing myofibrils, but also have immature smooth muscle cells similar to those seen in the uterus of a fetus at 18 to 20 weeks of pregnancy. It is speculated that the occurrence of human uterine myomas may be from undifferentiated mesenchymal cells in the uterus, which proliferate under certain pathological conditions and differentiate into smooth muscle cells to form uterine myomas.

Compared with histology, all cases of chromosomal abnormalities showed benign tumors in histology. Although they were all benign tumors, their chromosomes showed a certain degree of heterogeneity. 80% of uterine fibroids with special histological types were found to have abnormal karyotypes, while those with typical histological cases were relatively rare. The heterogeneity of cytogenetics suggests that many different somatic mutations may be involved in the occurrence of uterine fibroids, and a single somatic mutation in an individual fibroid may be the biological basis for the different responses of individual fibroids to different growth-promoting factors.

The above is the cause of uterine fibroids briefly introduced by the experts. I believe you already know it. If you have any questions about uterine fibroids, please consult our online experts. We will serve you wholeheartedly!

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