Why does hydatidiform mole form?

The formation of hydatidiform mole is closely related to genetic abnormalities, environmental factors, and physiological and pathological factors. It is an abnormal pregnancy that is directly related to chromosomal abnormalities during the formation of the fertilized egg, and may also be affected by the environment or the mother's physical condition. Early diagnosis and intervention are key, and can be detected through ultrasound examinations, blood tests, etc., and resolved through drug treatment, curettage, etc. when necessary.

1Genetic factors are the main reason

The formation of hydatidiform mole is mostly related to chromosomal abnormalities. A normal fertilized egg should contain 23 chromosomes from the father and 23 from the mother, while a complete hydatidiform mole is usually caused by a lack of chromosomes in the egg, and the genetic material of the embryo after fertilization comes entirely from the father. Another possibility is a partial hydatidiform mole, which is caused by two sperm fertilizing at the same time, resulting in an abnormal number of chromosomes. These genetic errors directly lead to the embryo's inability to develop normally, forming a hydatidiform mole.

2. Interference from environmental factors

Some pathogenic factors in the environment may increase the risk of hydatidiform mole. For example, long-term malnutrition, smoking, drinking or exposure to chemical pollutants may interfere with the normal division of female reproductive cells. Selenium deficiency in the soil in some areas is also believed to be related to the high incidence of hydatidiform mole, especially in economically underdeveloped areas. This is worth noting.

3. Influence of physiological or pathological factors

Maternal age is another important factor in the occurrence of hydatidiform mole. Women under 20 or over 40 are more likely to have it. The risk of hydatidiform mole increases significantly when a woman with a history of hydatidiform mole becomes pregnant again. At the same time, abnormal maternal hormone secretion or excessive proliferation of ectopic tissue in the uterus may also lead to the occurrence of hydatidiform mole.

Treatment and prevention advice

1. Uterine curettage: Uterine curettage should be performed as soon as possible after diagnosis to remove abnormal embryonic tissue and confirm the diagnosis through pathological sections.

2 Drug treatment: Serum β-HCG levels need to be monitored regularly after surgery. If they have not completely decreased or signs of lung metastasis appear, chemotherapy drugs such as methotrexate or fluorouracil are needed for intervention.

3 Follow-up monitoring: Avoid pregnancy within 6 months to 1 year after surgery, check serum indicators monthly, and pay attention to whether there is a trend of malignant transformation.

Hydatidiform mole is mostly caused by errors in the process of gene and cell division. Understanding its cause can help better prevent and treat it. After diagnosis, you need to actively communicate with your doctor about the treatment plan and pay attention to postoperative follow-up to avoid complications.