Experts explain how to prevent hyperprolactinemia

Hyperprolactinemia has a great impact on women's lives. If the disease is not treated early, it may develop into a macroadenoma. Moreover, this disease is difficult to treat. Preventing the occurrence of hyperprolactinemia has become a key issue. What are the prevention methods? Let's listen to the experts' introduction.

Pituitary PRL tumor is the most common cause of high PRL blood. Foreign data show that the prevalence of PRL tumors with clinical symptoms is about 1/5000, and the onset age of most PRL tumors is between 30 and 50 years old. About 65% of PRL tumors are microadenomas, and they are almost only seen in women; the other 35% are macroadenomas, and there is no gender difference in their incidence. Long-term follow-up of PRL microadenomas shows that if not treated, about 7% of microadenomas will develop into macroadenomas. Cause: The most common cause of high PRL blood is pituitary PRL tumor. Like other pituitary adenomas, the causes of PRL tumors also include abnormalities of PRL cells themselves and hypothalamic dysfunction. In terms of pituitary abnormalities, the most important is the mutation of the Gsα gene. It has been found that about 1/3 of PRL tumors are caused by mutations in the Gsα gene. H-ras mutations may play a certain role in malignant PRL tumors, but it is not very significant in ordinary PRL tumors. It has been suspected that reduced hypothalamic dopaminergic activity is involved in the formation of PRL tumors, but this has not been confirmed. Since PRL microadenomas are almost only seen in women, it is believed that estrogen plays an important role in the formation of PRL tumors. Occasionally, PRL tumors can be one of the manifestations of multiple endocrine neoplasia type 1 (MENl). Sometimes there is no obvious cause for high PRL blood, which is called idiopathic high PRL blood. Some people believe that idiopathic high PRL blood is also caused by PRL microadenomas, but the tumor is very small and cannot be displayed with existing imaging techniques. Some people also believe that idiopathic high PRL blood is caused by hypothalamic dysfunction. Some people abroad have conducted long-term follow-up on idiopathic high PRL blood. The results showed that about half of the patients had no significant changes in blood PRL levels, about 1/3 of the patients had blood PRL levels dropped to normal, and about 15% of the patients had PRL microadenomas after 2 to 6 years.

The above introduces in detail the knowledge of prevention of high prolactin. This knowledge is very important for women. Knowing more about prevention can reduce the occurrence of high prolactin. Women should pay more attention to this in their daily lives.