Summary of Causes of Hyperprolactinemia

Hyperprolactinemia is a gynecological disease that can cause female infertility in severe cases. Today, let's learn about what hyperprolactinemia is, the causes of hyperprolactinemia, and the treatment of hyperprolactinemia. Let's learn about it together!

First of all, let's learn about what hyperprolactinemia is. I believe everyone should be unfamiliar with hyperprolactinemia! Let's learn about it!

Hyperprolactinemia

Hyperprolactinemia (HPPL) refers to a syndrome caused by internal and external environmental factors, characterized by elevated prolactin (PRL) (≥25ng/ml), amenorrhea, galactorrhea, anovulation and infertility.

Causes

Normal PRL pulsatile release and its circadian rhythm play an important regulatory role in mammary gland development, lactation and ovarian function.

After reading the above content, we should all have a general idea of ​​the cause of hyperprolactinemia. In fact, the cause of hyperprolactinemia is quite complicated. Let us continue to explain it to you below.

PRL secretion is regulated by both hypothalamic PRL-RH and PRL-IH. In a normal ovulatory menstrual cycle, PRL is always under the tonic inhibitory regulation of CNS hypothalamic dopaminergic neurotransmitters and PRL-IH. Once this regulation is unbalanced, HPPL is caused. HPRL can be caused by physiological and pathological factors.

Clinical manifestations

1. Menstrual disorders

Primary amenorrhea accounts for 4%, secondary amenorrhea accounts for 89%, oligomenorrhea and oligomenorrhea account for 7%, and functional uterine bleeding and luteal insufficiency account for 23% to 77%.

2. Breast leakage

Typical HPRL manifestations are amenorrhea-galactorrhea syndrome, accounting for 20.84% ​​of non-tumor type, 70.58% of tumor type, and 63% to 83.55% of simple galactorrhea. Galactorrhea is overt or occurs when the breast is squeezed, and is watery, serous, or milky. The breasts are mostly normal, or with lobular hyperplasia or macromastia.

3. Infertility

Patients with hyperprolactinemia may be infertile, which is a very serious consequence for women. Let's take a look at how to check it.

It is caused by anovulation, luteal insufficiency or luteinized unruptured follicle syndrome (LUFS).