Estrogen for the treatment of functional uterine bleeding in adolescence

Dysfunctional uterine bleeding in adolescence is mainly treated conservatively. Currently commonly used methods include artificial cycle therapy with traditional Chinese medicine, hormone therapy, etc. Estrogen can be used to treat functional uterine bleeding in adolescence.

Effects of estrogen

The use of large doses of estrogen can quickly increase the estrogen concentration in the blood, promote the growth of the endometrium, repair the wound and stop bleeding in a short period of time. It is suitable for those with endogenous estrogen deficiency and can also be used to treat functional uterine bleeding in adolescence.

How to use estrogen

At present, the most commonly used drugs are conjugated estrogen 1.25-2.5 mg, once every 6 hours, and the amount is reduced by 1/3 every 3 days after the bleeding stops, until the maintenance dose is 0.625-1.25 mg/day. Diethylstilbestrol 1-2 mg can also be used, once every 6-8 hours, and the amount is reduced by 1/3 every 3 days after the bleeding stops, and the maintenance dose is 1 mg; the disadvantage of taking a large amount of diethylstilbestrol orally is that the gastrointestinal reaction is severe, the drug absorption is slow, and it is not easy to take effect quickly. If necessary, micronized 17β-estradiol, conjugated estrogen, or estradiol benzoate 4-8 mg/day can be taken orally, divided into 2 intramuscular injections, and the daily dose is reduced by 2 mg to 2 mg/day, and then diethylstilbestrol is used to maintain the dose of 1 mg/day.

Medication time for adolescent functional uterine bleeding

All the above-mentioned methods of administration are applied until 20 days after hemostasis, and can be appropriately extended for anemia. Regardless of the type of estrogen treatment used, progestogen is added 2 weeks after hemostasis to convert the endometrium into the secretory phase. Oral medroxyprogesterone 10 mg can be used once a day or intramuscular injection of progesterone 10 mg once a day, and both are stopped for 7-10 days. The simultaneous withdrawal of estrogen and progesterone is conducive to the synchronous shedding of the endometrium, and withdrawal bleeding usually occurs 3-7 days after stopping the drug.