What are the drugs for treating adenomyosis?

Introduction to common drugs for the treatment of adenomyosis The following introduces some common drugs that are often used in the treatment of adenomyosis. I hope you will know more about them. As a common gynecological disease, adenomyosis is a benign cancer, but its impact on patients cannot be underestimated. If treatment is not taken in time, malignant lesions may also occur, which is very unfavorable for patients.

The following introduces some common medicines that are often used in the treatment of adenomyosis. I hope you can understand them better.

Danazol: This drug can block the synthesis and release of pituitary gonadotropin, directly inhibit the synthesis of ovarian hormones, and can bind to the endometrial estrogen and progesterone receptors, thereby shrinking the endometrium and causing patients to undergo temporary menopause, also known as pseudomenopause therapy. It can effectively relieve pain. Adverse reactions include weight gain, edema, breast reduction, hirsutism, hot flashes, and decreased libido. However, the incidence is low and the symptoms are mostly not serious. Regularly check liver function during medication and stop taking the drug if liver damage occurs.

Gestrogens: This drug has anti-estrogen and anti-progestin effects, and also has androgen-like activity. It can inhibit the release of gonadotropins, causing ovarian secretion inhibition, and a decrease in the levels of estrogen and progesterone in the blood. In addition, it can directly act on the receptors of endometrial and ectopic endometrial cells, exerting anti-progestin and anti-estrogen effects, thereby shrinking the eutopic and ectopic endometrium. The incidence of adverse reactions is the same as that of danazol, but the degree is slightly less. It has been widely used in recent years.

Gonadotropin-releasing hormone agonist: This drug can maintain a low estrogen state in the body for a long time, eliminating the supporting and stimulating effects of estrogen on adenomyosis lesions, thereby shrinking and atrophying the lesions. At the same time, estrogen and progesterone) and reverse reduction therapy are added to make the estrogen level in the body reach the window dose. It does not affect the treatment of adenomyosis, and can minimize the side effects of estrogen.

Mifepristone: This drug is a progesterone receptor antagonist that inhibits angiogenesis. In recent years, some experts believe that mifepristone can treat perimenopausal adenomyosis for 3 months, and the symptoms of dysmenorrhea disappear, the patient stops menstruating, and the uterus is significantly reduced. During the medication period, some patients may experience an increase in alanine aminotransferase, an indicator of liver function, but it is mostly within 100U/L and is transient. After stopping the medication, it returns to normal.

L-18-methylnorgestrel: a subcutaneous implant that can treat perimenopausal adenomyosis. Although the uterine volume does not decrease significantly after treatment, the dysmenorrhea relief rate can reach 100%. It should be less than that of traditional intrauterine devices, mainly breakthrough bleeding, which often occurs in the first 6 months after placement.

Methotrexate: This drug can reduce the thickness of the uterus and the thickness of the posterior wall.

The above is an introduction to the common medicines used in the treatment of adenomyosis. Please choose according to your doctor's advice and your condition.